Results 91 to 100 of about 22,889 (244)

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

A temperature-sensitive phase-change hydrogel of topotecan achieves a long-term sustained antitumor effect on retinoblastoma cells

OncoTargets and Therapy, 2019
Background Retinoblastoma (Rb) is one of the most common malignancies among children. Following early diagnosis and prompt treatment, the clinical outcome or prognosis of Rb is promising.
Y. Huo, Qun Wang, Y. Liu, Junyi Wang, Qian Li, Zongyuan Li, Yan Dong, Yifei Huang, Liqiang Wang   +8 more
semanticscholar   +1 more source

Intrathecal topotecan in adult patients with neoplastic meningitis

, 2010
PURPOSE: The efficacy and safety of intrathecal topotecan were assessed in patients with neoplastic meningitis (NM) by retrospective chart review. SUMMARY: Fourteen patients (median age, 57 years) with NM were treated with the standard of care (i.e ...
Gammon, David C., Bhatt, Mansi S., Van Horn, Alexis, Benvenuti, Matthew, Tran, Lan, Glantz, Michael J.   +5 more
core   +1 more source

Practice‐Changing Advances in Systemic Therapies Shaping the Landscape of Lung Cancer in 2025

Cancer Innovation, Volume 5, Issue 3, June 2026.
This review synthesizes 2025 breakthroughs in systemic therapies of lung cancer, especially in targeted and immunotherapies, accelerating mortality decline across non‐small cell lung cancer and small cell lung cancer stages. ABSTRACT With the rapid advancement of molecular profiling and precision therapeutics, targeted and immunotherapeutic strategies ...
Zhenyu Zhou, Wanting Gao, Molly S. C. Li, Qing Zhou   +3 more
wiley   +1 more source

Efficacy and Safety of Rovalpituzumab Tesirine Compared with Topotecan as Second-Line Therapy in DLL3-High Small Cell Lung Cancer: Results from the Phase 3 TAHOE Study.

Journal of Thoracic Oncology, 2021
F. Blackhall, K. Jao, L. Greillier, B. Cho, K. Penkov, N. Reguart, M. Majem, K. Nackaerts, K. Syrigos, K. Hansen, W. Schuette, J. Cetnar, F. Cappuzzo, I. Okamoto, M. Erman, S. Langer, T. Kato, H. Groen, Zhaowen Sun, Yan Luo, P. Tanwani, L. Caffrey, P. Komarnitsky, N. Reinmuth   +23 more
semanticscholar   +1 more source

Folic acid-conjugated mesoporous silica nanoparticles for enhanced therapeutic efficacy of topotecan in retina cancers

International Journal of Nanomedicine, 2018
In this study, topotecan-loaded mesoporous silica nanoparticles were prepared and surface conjugated with folic acid (FTMN) to enhance the therapeutic efficacy of topotecan for the treatment of retinoblastoma (RB) cancers.
Wei Qu, Bo Meng, Yangyang Yu, Shaowei Wang   +3 more
semanticscholar   +1 more source

Topotecan and Ginkgolic Acid Inhibit the Expression and Transport Activity of Human Organic Anion Transporter 3 by Suppressing SUMOylation of the Transporter

Pharmaceutics
Organic anion transporter 3 (OAT3), expressed at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous metabolites, environmental toxins, and clinically important drugs.
Zhou Yu, Guofeng You
doaj   +1 more source

Determination of Topotecan by ELISA.

Biological and Pharmaceutical Bulletin, 2001
A highly sensitive ELISA for the determination of (s)-9-dimethylaminomethyl-10-hydroxy-camptothecin (topotecan) capable of measuring as low as 80 pg/ml was developed. Anti-topotecan antibody was obtained by immunizing rabbits with topotecan conjugated with bovine serum albumin using diazotized m-aminobenzoic acid as a cross-linker.
SAITA, Tetsuya, FUJITO, Hiroshi, MORI, Masato   +2 more
openaire   +3 more sources

Mathematical models characterising the kinetics and dynamics of topotecan to account for drug resistance mechanisms [PDF]

This thesis describes the use of mathematical modelling in studying the kinetics and dynamics of the anti-cancer agent topotecan (TPT), a semi-synthetic derivative of the natural extract camptothecin (CPT), which has been found to act as an inhibitor ...
Atari, M. I. (Mohammed Isam)
core