Results 61 to 70 of about 13,887 (161)
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.Dual‐drug‐loaded liposomes enable the simultaneous delivery of hydrophilic and hydrophobic therapeutics to tumors, enhancing anticancer efficacy and overcoming multidrug resistance. Through rational formulation design and surface functionalization, these systems improve tumor targeting, modulate efflux mechanisms and EMT, and achieve synergistic ...
Neelam Sinha +4 more
wiley +1 more source
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang +6 more
wiley +1 more source
Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma +6 more
wiley +1 more source
Case Reports in Oncology, 2014 Introduction: Recurrent cervical cancer is associated with a poor prognosis. Most treatment responses are partial and of short duration. The development of new therapies is vital to improve treatment for recurrent disease.
Donato Callegaro-Filho +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1733-1735, August 2026.ABSTRACT Friedreich Ataxia (FRDA) is a neurodegenerative disorder of children and young adults associated with cardiomyopathy and other systemic complications. We report a 10‐year‐old girl who presented simultaneously with Acute Myelogenous Leukemia and FRDA who was successfully treated for her leukemia with allogeneic hematopoietic stem cell ...
Alexandra Gitman +5 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 8, August 2026.Chest contrast‐enhanced computed tomography. A slightly enhanced solid intraluminal mass is observed in the left (green arrow) and right (yellow arrow) main pulmonary arteries. ABSTRACT We report a case of pulmonary artery intimal sarcoma successfully treated with surgical resection followed by weekly paclitaxel.
Fumitaka Endo +6 more
wiley +1 more source
Cancer, Volume 132, Issue 15, 1 August 2026.ABSTRACT Background Lung metastases in patients with metastatic rhabdomyosarcoma (RMS) have not been treated uniformly across Europe. This provides comparison of the impact of whole lung irradiation (WLI). Methods Lung‐metastatic patients included in the Cooperative Weichteilsarkom Studiengruppe‐IV 2002, European Pediatric Soft Tissue Sarcoma Study ...
Amadeus T. Heinz +14 more
wiley +1 more source
Precision post‐translational modification of PML defines neuroblastoma clinical behaviour
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Promyelocytic leukaemia protein (PML) loss is significantly associated with advanced disease stage, metastasis, relapse, therapy resistance, and poor survival in neuroblastoma. Elevated phosphorylation of PML at S518 promotes PML destabilisation and predicts adverse clinical outcomes. The phosphorylated PML (pPML)/PML ratio provides enhanced prognostic
Sreenidhi Mohanvelu +6 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2020 While topotecan (TPT) is a first- and second-line chemotherapeutic drug in treating lung cancer, the development of drug resistance in tumors still reserves as a major obstacle to chemotherapeutic success.
Zi-Ning Lei +12 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu +7 more
wiley +1 more source