Results 111 to 120 of about 22,889 (244)

Copper-topotecan complexation : development of a novel liposomal fromulation of topotecan

, 2006
Previously it has been reported that transition metal complexation reactions can be used as a method to encapsulate the anticancer drug doxorubicin into liposomes.
Taggar, Amandeep S.
core  

Effective Dosing of Topotecan With Carboplatin in Relapsed Ovarian Cancer: A Phase I/II Study

, 2001
PURPOSE: This phase I/II study was performed to evaluate the feasibility of administering the topoisomerase inhibitor topotecan in combination with carboplatin.
A. Bowman, G. Ross, T. Rye, A. Wheatley, J. F. Smyth   +4 more
core   +1 more source

Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models

Neoplasia: An International Journal for Oncology Research, 2005
To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we performed a comparative study of topotecan and gimatecan in human bladder cancer models (HT1376 and
Paola Ulivi, Wainer Zoli, Francesco Fabbri, Giovanni Brigliadori, Luca Ricotti, Anna Tesei, Marco Rosetti, Michelandrea De Cesare, Giovanni L. Beretta, Elisabetta Corna, Rosanna Supino, Franco Zunino   +11 more
doaj   +1 more source

No evidence that amifostine influences the plasma pharmacokinetics of topotecan in ovarian cancer patients

, 2002
Objective: This aim of this study was to compare the pharmacokinetics of topotecan in the presence and absence of preceding amifostine to reduce the risk of side effects in patients with advanced ovarian cancer.
Zackrisson, Anna-Lena, Malmström, Henric,, Peterson, Curt   +2 more
core   +1 more source

Topotecan in a Real-World Small-Cell Lung Cancer Cohort: Prognostic Biomarkers Improve Selection of Patients for Second-Line Treatment

Diagnostics
Background: Small-cell lung cancer (SCLC) is a highly aggressive tumor, and overall survival (OS) remains poor despite intensive efforts to develop new treatment strategies.
Laura Lambrecht, Paola Arnold, Jürgen Behr, Pontus Mertsch, Amanda Tufman, Diego Kauffmann-Guerrero   +5 more
doaj   +1 more source

Voltammetric Studies of Topotecan Transfer Across Liquid/Liquid Interfaces and Sensing Applications

, 2015
An amperometric ion sensor featuring a microhole supported water/organic gel interface was developed for the quantitative analysis of a water-soluble anticancer drug species, namely, topotecan, which has been used for ovarian and lung cancer treatments ...
Carlos M. Pereira (1598554), Hye Rim Kim (225882), Hye Jin Lee (67018), Hye Youn Han (1598551)   +3 more
core   +1 more source

Neuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside

OncoImmunology, 2018
Despite recent advances in high-risk neuroblastoma therapy, the prognosis for patients remains poor. In addition, many patients suffer from complications related to available therapies that are highly detrimental to their quality of life.
S. Faraj, M. Bahri, S. Fougeray, A. El Roz, J. Fleurence, J. Véziers, M. D. Leclair, E. Thébaud, F. Paris, S. Birklé   +9 more
doaj   +1 more source

FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11

Acta Pharmacologica Sinica, 2021
Yan-Ping Yin, Li-ying Ma, Guoping Cao, Jinghan Hua, Xiaotong Lv, Wenchu Lin   +5 more
semanticscholar   +1 more source

Topotecan in second-line therapy of SCLC: Impact on survival? [PDF]

, 2000
Kleinschmidt, R., Hruska, D., Mezger, J., Pawel, J. von, Saal, J. G., Gatzemeier, U., Steppling, H., Huber, Rudolf M., Gosse, H., Steppert, C.   +9 more
core   +1 more source

Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.

, 1996
PURPOSE To determine the maximum-tolerated systemic exposure (MTSE) and exposure-limiting toxicity of continuous infusion topotecan in children with recurrent acute leukemia.
W E Evans, C B Pratt, S D Baker, W L Furman, C F Stewart, G K Rivera   +5 more
core   +1 more source