Results 101 to 110 of about 25,780 (241)

Novobiocin Sensitizes Bcrp/Mxr/Abcp Overexpressing Topotecan-Resistant Human Breast Carcinoma Cells to Topotecan and Mitoxantrone

, 2009
Background : Novobiocin was shown to sensitize cancer cells to etoposide and alkylating agents. Human breast carcinoma cells exposed to topotecan ( MCF7/TPT-300 cells) developed resistance to both mitoxantrone and topotecan.
YANG, CHIH-HSIN;CHEN, YAO-CHANG;KUO, MIN-LIANG, 楊志新;陳耀昌;郭明良   +1 more
core  

Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer

BMC Cancer, 2007
Background A platinum doublet is the current standard treatment for good performance status patients with advanced non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (SCLC) with good performance status.
Kraft Andrew S, Meyer Mario L, Chaudhary Uzair, Garrett-Mayer Elizabeth, Green Mark R, Sherman Carol A, Beldner Matthew A, Montero Alberto J   +7 more
doaj   +1 more source

No evidence that amifostine influences the plasma pharmacokinetics of topotecan in ovarian cancer patients

, 2002
Objective: This aim of this study was to compare the pharmacokinetics of topotecan in the presence and absence of preceding amifostine to reduce the risk of side effects in patients with advanced ovarian cancer.
Zackrisson, Anna-Lena, Malmström, Henric,, Peterson, Curt   +2 more
core   +1 more source

Systematic Review and Network Meta-Analysis of Bevacizumab Plus First-Line Topotecan-Paclitaxel or Cisplatin-Paclitaxel Versus Non–Bevacizumab-Containing Therapies in Persistent, Recurrent, or Metastatic Cervical Cancer

International Journal of Gynecologic Cancer, 2017
Objective Despite advances in cervical cancer prevention and diagnosis, outcomes for patients given a diagnosis of advanced and recurrent disease are poor.
V. Rosen, I. Guerra, M. McCormack, A. Nogueira-Rodrigues, A. Sasse, V. C. Munk, A. Shang   +6 more
semanticscholar   +1 more source

The Anti-Proliferative and Pro-apoptotic Effect of Topotecan in Combination With Thymoquinone in Acute Myelogenous Leukemia

, 2016
Topotecan (a novel topoisomerase I inhibitor and a water-soluble camptothecin analog) is active against numerous human tumor cell lines, and has shown promising antineoplastic activity in solid tumors and acute leukemia.
Tarras, Omayr, Rizk, Sandra, Khalife, Rana   +2 more
core   +1 more source

Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models

Neoplasia: An International Journal for Oncology Research, 2005
To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we performed a comparative study of topotecan and gimatecan in human bladder cancer models (HT1376 and
Paola Ulivi, Wainer Zoli, Francesco Fabbri, Giovanni Brigliadori, Luca Ricotti, Anna Tesei, Marco Rosetti, Michelandrea De Cesare, Giovanni L. Beretta, Elisabetta Corna, Rosanna Supino, Franco Zunino   +11 more
doaj   +1 more source

The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines

International Journal of Molecular Sciences, 2018
The major cause of ovarian cancer treatment failure in cancer patients is inherent or acquired during treatment drug resistance of cancer. Matrix Gla protein (MGP) is a secreted, non-collagenous extracellular matrix protein involved in inhibition of ...
K. Sterzyńska, A. Klejewski, K. Wojtowicz, M. Świerczewska, Małgorzata Andrzejewska, Damian Rusek, M. Sobkowski, W. Kędzia, J. Brązert, M. Nowicki, R. Januchowski   +10 more
semanticscholar   +1 more source

Topotecan-Vincristine-Doxorubicin in Stage 4 High-Risk Neuroblastoma Patients Failing to Achieve a Complete Metastatic Response to Rapid COJEC: A SIOPEN Study

Cancer research and treatment : official journal of Korean Cancer Association, 2017
Purpose Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete response (CR)
L. Amoroso, G. Erminio, G. Makin, A. Pearson, P. Brock, D. Valteau-Couanet, V. Castel, M. Pasquet, G. Laureys, C. Thomas, R. Luksch, R. Ladenstein, R. Haupt, A. Garaventa   +13 more
semanticscholar   +1 more source

Topotecan in a Real-World Small-Cell Lung Cancer Cohort: Prognostic Biomarkers Improve Selection of Patients for Second-Line Treatment

Diagnostics
Background: Small-cell lung cancer (SCLC) is a highly aggressive tumor, and overall survival (OS) remains poor despite intensive efforts to develop new treatment strategies.
Laura Lambrecht, Paola Arnold, Jürgen Behr, Pontus Mertsch, Amanda Tufman, Diego Kauffmann-Guerrero   +5 more
doaj   +1 more source

Combined effect of topotecan and irradiation on the survival and the induction of chromosome aberrations in vitro

, 2002
Background: Topotecan demonstrated radiosensitizing effects in vivo and in vitro, which are schedule- and cell Line dependent. The underlying mechanisms are not fully understood.
Glomme, S., Virsik-Koepp, Patricia, Hertig, J., Weiss, Elisabeth, Pradier, Olivier, Schmidberger, Heinz, Rave-Fraenk, Margret, Hess, C. F.   +7 more
core   +1 more source