Results 91 to 100 of about 25,780 (241)
CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K/AKT Pathway
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Background Epithelial ovarian cancer (EOC) frequently disseminates within the lipid‐rich peritoneal cavity, where tumor progression is accompanied by metabolic adaptations involving lipid utilization and mitochondrial function. Although these metabolic alterations are increasingly recognized as important features of EOC progression and ...
Lixue Cao +10 more
wiley +1 more source
Assessment of Anti-Cytogenotoxic Effects of Quercetin in Animals Treated with Topotecan [PDF]
, 2011 The present investigation was directed to study the possible chemoprotective activity of orally administered quercetin against topotecan-induced cyto- and genotoxicity towards mouse somatic cellsin vivo.
Saleh A. Bakheet
core +1 more source
Pharmaceuticals, 2020 Topotecan is actively used in clinic, with its primary use being in treatment of various types of cancer. The approved administration routes are oral and intravenous.
Seung-Hyun Jeong +2 more
doaj +1 more source
OncoTargets and Therapy, 2019 Background Retinoblastoma (Rb) is one of the most common malignancies among children. Following early diagnosis and prompt treatment, the clinical outcome or prognosis of Rb is promising.
Y. Huo +8 more
semanticscholar +1 more source
Intrathecal topotecan in adult patients with neoplastic meningitis
, 2010 PURPOSE: The efficacy and safety of intrathecal topotecan were assessed in patients with neoplastic meningitis (NM) by retrospective chart review. SUMMARY: Fourteen patients (median age, 57 years) with NM were treated with the standard of care (i.e ...
Gammon, David C. +5 more
core +1 more source
PharmaceuticsOrganic anion transporter 3 (OAT3), expressed at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous metabolites, environmental toxins, and clinically important drugs.
Zhou Yu, Guofeng You
doaj +1 more source
Determination of Topotecan by ELISA.
Biological and Pharmaceutical Bulletin, 2001 A highly sensitive ELISA for the determination of (s)-9-dimethylaminomethyl-10-hydroxy-camptothecin (topotecan) capable of measuring as low as 80 pg/ml was developed. Anti-topotecan antibody was obtained by immunizing rabbits with topotecan conjugated with bovine serum albumin using diazotized m-aminobenzoic acid as a cross-linker.
SAITA, Tetsuya +2 more
openaire +3 more sources
Topotecan uptake and efflux in topotecan resistant cancer cells
, 2000 喜樹鹼能抑制第一型拓蹼異構酵素，在實驗室中可抑制癌細胞生長。Topotecan及CPT-11 是兩個喜樹鹼的衍生物，最近已 開發成功。Topotecan 可治療卵巢癌而CPT-11 可治療大腸癌。目前二者都使用在各種癌症的臨床試驗，以尋求更廣泛的適 應症。以喜樹鹼置於癌細胞生長培養液中，往往產生對所有喜樹鹼衍生物的抗藥性。進一步分析可發現，抗藥性癌細胞中，第一型拓蹼異構酵素可能會下降或是產生突變，以致對喜樹鹼抑制劑的敏感度下降。我們先前發現，以第二型拓蹼異構酵素抑制劑mitoxantrone ...
楊志新
core
International Journal of Nanomedicine, 2018 In this study, topotecan-loaded mesoporous silica nanoparticles were prepared and surface conjugated with folic acid (FTMN) to enhance the therapeutic efficacy of topotecan for the treatment of retinoblastoma (RB) cancers.
Wei Qu +3 more
semanticscholar +1 more source
, 2021 Intrathecal administration of anticancer drugs is an effective dosage strategy, but the elimination of intraventricular drugs is not uniform in all patients.
Mariko Kinoshita +6 more
core +1 more source