Results 41 to 50 of about 29,205 (261)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
ActuatorsThis paper proposes a high torque density dual-stator flux-reversal-machine with multiple poles Halbach excitation (MPHE-DSFRM), which uses two pole pairs’ numbers (PPNs) of PM excitation on one outer stator tooth, and one PPN of PM excitation on one ...
Siwei Tang +3 more
doaj +1 more source
Influence of cortical thickness on the stability of mini-implants with microthreads
Brazilian Oral Research, 2015 The objective of this study was to assess the influence of cortical thickness and bone density on the insertion torque of a mini-implant (MI) with microthreads. Mini-implants with lengths of 6 and 8 mm in the active part were inserted into synthetic bone
Giselle Naback Lemes VILANI +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Xibei Gongye Daxue Xuebao, 2021 The traditional optimal design of a transverse magnetic field motor mainly uses the electromagnetic relational formulas and the finite element analysis to empirically select its structural parameters, therefore making it difficult to obtain the global ...
Yuan Xiaoqing +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Analytical Formulation for Optimisation of Torque Density in Magnetic Gears
Jurnal Kejuruteraan, 2023 Energy efficiency is a very important consideration in vehicle design today. Minimizing weight would go a long way in this direction, as it directly contributes up to 75% of fuel consumption. Mechanical gearboxes and transmissions are components that add significantly to vehicle weight.
Nuraqilah Nasuha Salimin +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Design Analysis of a Dual Rotor Permanent Magnet Machine driven Electric Vehicle
MATEC Web of Conferences, 2018 Electric bike in urban countries such as Europe and China commonly used the brushless direct current machine (BLDC) as it able to produce high torque to transport the user from one place to another.
Izzat Bin Zainuddin Mohd, Aravind CV
doaj +1 more source