Results 11 to 20 of about 480,913 (287)

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study [PDF]

Circulation, 2017
Background -Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications.
D. Strauss, J. Vicente, L. Johannesen, K. Blinova, J. Mason, P. Weeke, E. Behr, Dan M. Roden, R. Woosley, Gülüm Kosova, M. Rosenberg, C. Newton‐Cheh   +11 more
semanticscholar   +3 more sources

Effect of COVID‐19 medications on corrected QT interval and induction of torsade de pointes: Results of a multicenter national survey

International journal of clinical practice, 2021
There are some data showing that repurposed drugs used for the Coronavirus disease‐19 (COVID‐19) have potential to increase the risk of QTc prolongation and torsade de pointes (TdP), and these arrhythmic side effects have not been adequately addressed in
M. Haghjoo, Reza Golipra, J. Kheirkhah, Allahyar Golabchi, Javad Shahabi, Saeed Oni-Heris, Ramin Sami, Marzieh Tajmirriahi, M. Saravi, Mozhdeh Khatami, Mehran Varnasseri, Mohammad Kiarsi, Seyed Fakhreddin Hejazi, Mojtaba Yousefzadeh Rahaghi, Maryam Taherkhani, H. Ashraf, M. Keshmiri, M. Akbarzadeh, A. Bozorgi, Fatemeh Mottaghizadeh, Behnam Hedayat, M. Heidarali, Azita Hajhossein Talasaz   +22 more
semanticscholar   +1 more source

Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles [PDF]

, 2017
Early Afterdepolarizations, EADs, are defined as the reversal of the action potential before completion of the repolarization phase, which can result in ectopic beats.
Panfilov, Alexander, Seemann, Gunnar, Van Nieuwenhuyse, Enid, Vandersickel, Nele   +3 more
core   +14 more sources

Torsade de pointes [PDF]

Emergency Medicine Journal, 2002
A case is described of torsade de pointes in a 41 year old woman with pre-existing QTc prolongation, potentially exacerbated by treatment with sotalol. Previous cardiac investigations had been normal and after a second episode of ventricular fibrillation the patient was referred for electrophysiological studies.
P T, Munro, C A, Graham
openaire   +2 more sources

QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin

Heart Rhythm, 2020
Background There is no known effective therapy for patients with COVID-19. Initial reports suggesting the potential benefit of Hydroxychloroquine/Azithromycin (HY/AZ) have resulted in massive adoption of this combination worldwide ...
E. Chorin, Lalit Wadhwani, S. Magnani, Matthew Dai, E. Shulman, C. Nadeau-Routhier, R. Knotts, Roi Bar-Cohen, Edward V. Kogan, Chirag R. Barbhaiya, A. Aizer, Douglas S. Holmes, S. Bernstein, Michael A. Spinelli, David S. Park, Carugo Stefano, L. Chinitz, Lior Jankelson   +17 more
semanticscholar   +1 more source

Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes

Journal of Pharmacological Sciences, 2020
It has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes. We assessed proarrhythmic effects of terfenadine (30 mg/kg, p.o.) with/without ketoconazole (100 mg/kg, p.o.) pretreatment ...
Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi Sugiyama   +8 more
doaj   +1 more source

Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning

bioRxiv, 2020
Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of hERG channel block in vitro and QT interval prolongation in vivo for all ...
Alex Fogli Iseppe, H. Ni, Sicheng Zhu, Xianwei Zhang, R. Coppini, Pei-Chi Yang, U. Srivatsa, Colleen E. Clancy, A. Edwards, S. Morotti, E. Grandi   +10 more
semanticscholar   +1 more source

In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys

Journal of Pharmacological Sciences, 2020
We analyzed the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action using the chronic atrioventricular block cynomolgus monkeys with a cross ...
Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama   +9 more
doaj   +1 more source

Torsades de Pointes [PDF]

The Journal of Medical Research, 2018
History of present illness: 70-year-old male with a history ventricular arrhythmia, AICD (automated implantable cardioverter defibrillator), coronary artery disease and cardiac stents presented to the Emergency Department after three AICD discharges with dyspnea but no chest pain.
Pradnya Brijmohan Bhattad, Vinay Jain
openaire   +5 more sources

Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs

Journal of Pharmacological Sciences, 2020
We assessed torsadogenic action of risperidone, which can potently inhibit IKr as well as α1-adrenoceptor. A toxic dose of 3 mg/kg of risperidone was intravenously administered over 10 min to chronic atrioventricular block dogs without anesthesia with ...
Yoshio Nunoi, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Yoshinori Watanabe, Atsushi Sugiyama   +9 more
doaj   +1 more source