Results 21 to 30 of about 11,585 (220)

Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay

Journal of Pharmacological Sciences, 2016
We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3–30 mg/kg, i.v.
Yuji Nakamura, Rieko Sasaki, Xin Cao, Takeshi Wada, Shogo Hamaguchi, Hiroko Izumi-Nakaseko, Kentaro Ando, Hikaru Tanaka, Akira Takahara, Atsushi Sugiyama   +9 more
doaj   +1 more source

Torsade de pointes [PDF]

Clinical Cardiology, 1993
AbstractThe polymorphic ventricular tachycardia torsade de pointes can occur in the congenital long QT syndromes or as a consequence of therapy with QT‐prolonging drugs. The latter can include not only antiarrhythmic drugs such as quinidine, but also a number of drugs which are not usually considered to have major cardiovascular effects: these include ...
openaire   +2 more sources

Predictive Value of Tpeak – Tend Indices for Adverse Outcomes in Acquired QT Prolongation: A Meta-Analysis

Frontiers in Physiology, 2018
Background: Acquired QT interval prolongation has been linked with malignant ventricular arrhythmias, such as torsade de pointes, in turn predisposing to sudden cardiac death. Increased dispersion of repolarization has been identified as a pro-arrhythmic
Gary Tse, Gary Tse, Mengqi Gong, Lei Meng, Cheuk W. Wong, George Bazoukis, Matthew T. V. Chan, Martin C. S. Wong, Konstantinos P. Letsas, Adrian Baranchuk, Gan-Xin Yan, Gan-Xin Yan, Tong Liu, William K. K. Wu   +13 more
doaj   +1 more source

The U wave in atrial fibrillation [PDF]

, 2015
The U wave in ECGs of patients is difficult to observe because it is hidden under the atrial fibrillatory wave. Measurement and characteristics of the U wave in atrial fibrillation have not previously been described. Beat averaging was used to reveal the
Bourke, John P, Langley, Philip, Murray, Alan   +2 more
core   +2 more sources

Hypocalcemic torsades de pointes

Journal of Electrocardiology, 1989
Torsades de pointes is a unique form of ventricular tachycardia that occurs in the presence of prolonged QT interval. Many predisposing factors have been identified. A classical form of torsades de pointes occurring in the presence of hypocalcemia and prolonged QT interval in an elderly woman is reported.
T, Akiyama, J, Batchelder, J, Worsman, H W, Moses, M, Jedlinski   +4 more
openaire   +2 more sources

Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects

Journal of Pharmacological Sciences, 2018
We analyzed torsadogenic and pharmacokinetic profile of E-4031 using chronic atrioventricular block dogs. E-4031 in intravenous doses of 0.03, 0.1 and 0.3 mg/kg over 10 min prolonged QT/QTc, and increased short-term variability of QT in a dose-related ...
Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama   +6 more
doaj   +1 more source

R-from-T as a common mechanism of arrhythmia initiation in long QT syndromes [PDF]

, 2019
Background: Long QT syndromes (LQTS) arise from many genetic and nongenetic causes with certain characteristic ECG features preceding polymorphic ventricular tachyarrhythmias (PVTs).
Liu, Michael B., Panfilov, Alexander, Qu, Zhilin, Vandersickel, Nele   +3 more
core   +2 more sources

Bloqueio completo de ramo esquerdo, bloqueio auriculoventricular, torsade de pointes e QT longo: será demasiado para uma rara miocardiopatia?

Revista Portuguesa de Cardiologia, 2013
Resumo: O ventrículo esquerdo não compactado (VENC) tem sido reconhecido como uma forma distinta de miocardiopatia com uma apresentação clínica e história natural próprias.
Bruno Rodrigues, Emanuel Correia, Luís Ferreira Santos, Davide Moreira, Anne Delgado, Pedro Gama, António Costa, João Pipa, Oliveira Santos   +8 more
doaj   +1 more source

Prolonged QT Interval in a Patient With Coronavirus Disease-2019: Beyond Hydroxychloroquine and Azithromycin

Journal of Investigative Medicine High Impact Case Reports, 2020
Recent reports have suggested an increased risk of QT prolongation and subsequent life-threatening ventricular arrhythmias, particularly torsade de pointes, in patients with coronavirus disease-2019 (COVID-19) treated with hydroxychloroquine and ...
B K Anupama MBBS, Soumya Adhikari MBBS, Debanik Chaudhuri MD   +2 more
doaj   +1 more source

His Bundle Pacing in Amiodarone-Induced Complete Heart Block, QT Prolongation, and Torsade de Pointes

JACC: Case Reports, 2020
A woman with ischemic cardiomyopathy presented with recurrent syncope. Electrocardiogram showed complete heart block and torsade de pointes (TdP) secondary to amiodarone, recently started for paroxysmal atrial fibrillation.
Vern Hsen Tan, MBBS, CCDS, CEPS, Colin Yeo, MBBS, DRCPSC, Thuan Ngee Tan, MBBS, Diplomate CBNC, Diplomate CBCCT, Kelvin Wong, MB BChir, MD   +3 more
doaj   +1 more source