Results 41 to 50 of about 480,913 (287)

Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects

Journal of Pharmacological Sciences, 2018
We analyzed torsadogenic and pharmacokinetic profile of E-4031 using chronic atrioventricular block dogs. E-4031 in intravenous doses of 0.03, 0.1 and 0.3 mg/kg over 10 min prolonged QT/QTc, and increased short-term variability of QT in a dose-related ...
Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama   +6 more
doaj   +1 more source

Torsade de pointes and systemic azole antifungal agents: Analysis of global spontaneous safety reports

Global Cardiology Science & Practice, 2017
Background: Literature about torsade de pointes induced by azole antifungal agents is scarce, despite the well-known association. Furthermore, little is known about the latency time between commencing an azole antifungal agent and developing torsade de ...
M. Salem, T. Reichlin, D. Fasel, A. Leuppi-Taegtmeyer   +3 more
semanticscholar   +1 more source

Drugs and life-threatening ventricular arrhythmia risk: results from the DARE study cohort. [PDF]

, 2017
OBJECTIVES: To establish a unique sample of proarrhythmia cases, determine the characteristics of cases and estimate the contribution of individual drugs to the incidence of proarrhythmia within these cases.
Behr, ER, Camm, AJ, Coughtrie, AL, Layton, D, Marshall, V, Shakir, SAW   +5 more
core   +1 more source

Bloqueio completo de ramo esquerdo, bloqueio auriculoventricular, torsade de pointes e QT longo: será demasiado para uma rara miocardiopatia?

Revista Portuguesa de Cardiologia, 2013
Resumo: O ventrículo esquerdo não compactado (VENC) tem sido reconhecido como uma forma distinta de miocardiopatia com uma apresentação clínica e história natural próprias.
Bruno Rodrigues, Emanuel Correia, Luís Ferreira Santos, Davide Moreira, Anne Delgado, Pedro Gama, António Costa, João Pipa, Oliveira Santos   +8 more
doaj   +1 more source

Prolonged QT Interval in a Patient With Coronavirus Disease-2019: Beyond Hydroxychloroquine and Azithromycin

Journal of Investigative Medicine High Impact Case Reports, 2020
Recent reports have suggested an increased risk of QT prolongation and subsequent life-threatening ventricular arrhythmias, particularly torsade de pointes, in patients with coronavirus disease-2019 (COVID-19) treated with hydroxychloroquine and ...
B K Anupama MBBS, Soumya Adhikari MBBS, Debanik Chaudhuri MD   +2 more
doaj   +1 more source

His Bundle Pacing in Amiodarone-Induced Complete Heart Block, QT Prolongation, and Torsade de Pointes

JACC: Case Reports, 2020
A woman with ischemic cardiomyopathy presented with recurrent syncope. Electrocardiogram showed complete heart block and torsade de pointes (TdP) secondary to amiodarone, recently started for paroxysmal atrial fibrillation.
Vern Hsen Tan, MBBS, CCDS, CEPS, Colin Yeo, MBBS, DRCPSC, Thuan Ngee Tan, MBBS, Diplomate CBNC, Diplomate CBCCT, Kelvin Wong, MB BChir, MD   +3 more
doaj   +1 more source

The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model

, 2004
In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a
Cherry E. M., Diego J. M. D., Hervé Henry, Wouter-Jan Rappel   +3 more
core   +1 more source

Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Although atrial fibrillation (AF) is the most common abnormal heart rhythm and its prevalence continues to rise, there is a marked paucity of effective and safe antiarrhythmic drugs for AF.
Guizhi Liu, Xiaolin Xue, Chuanyu Gao, Jiaqi Huang, Datun Qi, Yanzhou Zhang, Jian‐Zeng Dong, Chang‐Sheng Ma, Gan‐Xin Yan   +8 more
doaj   +1 more source

Methadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case–Control Study [PDF]

, 2017
Background: Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adverse effects (AEs).
Brown, Jack, Hutchinson, David, Juba, Katherine, Khadem, Tina M.   +3 more
core   +2 more sources

Hepatite aguda alcoólica complicada com arritmia cardíaca. Alcool, hepatite, hipomagnesiemia, torsade de pointes, corticoterapia.

Acta Médica Portuguesa, 1994
The authors present the case of a 32-year-old woman, with acute alcoholic hepatitis(AAH), severe ionic changes and ventricular tachycardia torsade de pointes.
M J Morgado, A Marques, E Areias, M C Moura   +3 more
doaj   +1 more source