Results 71 to 80 of about 11,585 (220)

Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone

Case Reports in Medicine, 2012
We report a case of torsade de pointes after intravenous amiodarone and concurrent hypokalemia. Despite treatment cessation and correction of electrolyte abnormalities, excessive QTc prolongation was noted, which persisted for 14 days.
Anna P. Kotsia, Georgios Dimitriadis, Giannis G. Baltogiannis, Theofilos M. Kolettis   +3 more
doaj   +1 more source

Pärilik pika QT sündroom [PDF]

, 2013
Pärilik pika QT sündroom on geneetilise etioloogiaga südame elektrofüsioloogiline häire, mida iseloomustab EKGs QT-aja pikenemine, T-saki anomaaliad ning ventrikulaarse tahhükardia torsade de pointes’i tüüpi paroksüsmid koos sünkoobiga.
Jalas, Tiiu, Paju, Rain, Pajusalu, Sander, Reimand, Tiia, Õunap, Katrin, Žordania, Riina   +5 more
core   +2 more sources

Machine Learning‐Based Prediction of Drug‐Induced QTc Changes in a Large Finnish Biobank Cohort

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Prolongation of the QT interval is a known precursor to serious arrhythmias and sudden cardiac death, often triggered by medication use. Current medication risk evaluation platforms rely on literature‐based synthesis and may lag behind real‐world developments.
Ville Langén, Aleksi Winstén, Konsta Teppo, Timo Pohjonen, Jari Laukkanen, Arto Mannermaa, Teemu J. Niiranen, Joonatan Palmu   +7 more
wiley   +1 more source

Clarithromycin-Induced Long QT Syndrome: A Case Report

Case Reports in Medicine, 2012
Long QT syndrome develops for a number of reasons. The number of non-antiarrhythmic drugs reported to induce QT interval prolongation with or without torsade de pointes continues to increase.
Mecnun Cetin, Munevver Yıldırımer, Serkan Özen, Sema Tanrıverdi, Senol Coskun   +4 more
doaj   +1 more source

The QT interval in lightning injury with implications for the cessation of metabolism hypothesis [PDF]

An hypothesis is presented to provide an alternative to the Cessation of Metabolism hypothesis often invoked in lightning injury. Cessation of Metabolism has been proposed to explain the observation of good recovery after a prolonged period in cardiac ...
Andrews, Christopher J., Colquhoun, David M., Darveniza, Mat   +2 more
core   +1 more source

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]

, 2015
A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den, Eijgelsheim, M. (Mark), Niemeijer, M.N. (Maartje), Rijnbeek, P.R. (Peter), Stricker, B.H.Ch. (Bruno)   +4 more
core   +1 more source

Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This review presents a process‐oriented framework for vascularized cardiac tissue engineering, highlighting how the coordinated design of cells, biomaterials, and biofabrication strategies enables the functional development or vascularized myocardium for disease modelling and drug discovery.
Yang Liu, Zijie Zhang, Hongbin Li, Lino Prados‐Martin, Huanhong Li, Feng Cheng, Xia Tu, Khoon S. Lim, Wanlu Li, Mian Wang   +9 more
wiley   +1 more source

Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go–Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation

Journal of Pharmacological Sciences, 2008
QT prolongation, a risk factor for arrhythmias, can result from genetic variants in one (or more) of the genes governing cardiac repolarization as well as intake of drugs known to affect a cardiac K+ channel encoded by human ether-a-go-go–related gene ...
Tomoko Sakaguchi, Hideki Itoh, Wei-Guang Ding, Keiko Tsuji, Iori Nagaoka, Yuko Oka, Takashi Ashihara, Makoto Ito, Yoshihiro Yumoto, Naoko Zenda, Yukei Higashi, Youichi Takeyama, Hiroshi Matsuura, Minoru Horie   +13 more
doaj   +1 more source

Causal AI in Cardiac Arrhythmia: From Pattern Recognition to Mechanistic Insight

Clinical Cardiology, Volume 49, Issue 4, April 2026.
Causal artificial intelligence (AI) in Cardiac Arrhythmia: From Pattern Recognition to Mechanistic Insight. Multimodal cardiac data, including electrocardiograms (ECG), wearable device recordings, cardiac imaging, genetic information, and electronic health records, are integrated to support AI‐based analysis. Traditional AI approaches primarily rely on
Bara AbuBaha, Samia Aldwaik, Sarah Saife, Yousef Mahmoud‐Barqawi, Layan Omar, Omar Sawafta, Mohannad Sawalha, Hafez Nassar, Zeyad Alqasem, Karmel Khuffash, Hossam Salameh, Mohammed AbuBaha   +11 more
wiley   +1 more source

Sacubitril Does Not Exert Proarrhythmic Effects in Combination with Different Antiarrhythmic Drugs

Pharmaceuticals
Background: Previous studies suggest a direct effect of sacubitril on cardiac electrophysiology and indicate potential arrhythmic interactions between sacubitril and antiarrhythmic drugs.
Christian Ellermann, Carlo Mengel, Julian Wolfes, Felix K. Wegner, Benjamin Rath, Julia Köbe, Lars Eckardt, Gerrit Frommeyer   +7 more
doaj   +1 more source