Screening for QT Prolongation in the Emergency Department: Is There a Better “Rule of Thumb?” [PDF]
Introduction: Identification of QT prolongation in the emergency department (ED) is critical for appropriate monitoring, disposition, and treatment of patients at risk for torsades de pointes (TdP).
Friedman, Ari B. +2 more
core
Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Biliczki, Péter +10 more
core +1 more source
QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults
Journal of the American Geriatrics Society, EarlyView.
Francesco Fantin +7 more
wiley +1 more source
Prolactin Inhibition to Treat Postpartum Arrhythmic Storm
Postpartum electrical storm due to torsade de pointes is a rare but life-threatening condition. The uniqueness of this case lies in the use of cabergoline to suppress postpartum ventricular arrhythmias in absence of heart disease.
Miriam Compagnone, MD +9 more
doaj +1 more source
On-chip constructive cell-network study (II): on-chip quasi-in vivo cardiac toxicity assay for ventricular tachycardia/fibrillation measurement using ring-shaped closed circuit microelectrode with lined-up cardiomyocyte cell network [PDF]
Backgrounds Conventional in vitro approach using human ether-a-go-go related gene (hERG) assay has been considered worldwide as the first screening assay for cardiac repolarization safety.
Fumimasa Nomura +3 more
core +2 more sources
A repolarizációs rezerv csökkenésére és a kamrai repolarizáció adaptációs zavaraira visszavezethető proarrhytmiás mechanizmusok elemzése klinikai körülmények között és emlős szívizomban = Analysis of proarrhythmic mechanisms based on decreased repolarization reserve and disturbed adaptation of cardiac ventricular repolarization under clinical circumstances and in mammalian hearts [PDF]
Munkánk célja a kamrai repolarizáció - csökkent repolarizációs rezerv okozta - adaptációs zavarainak vizsgálata volt kísérletes és klinikai körülmények között.
Lengyel, Csaba Attila
core
Mapping and Ablating Ventricular Premature Contractions That Trigger Ventricular Fibrillation: Trigger Elimination and Substrate Modification [PDF]
Ventricular fibrillation (VF) is a malignant arrhythmia, usually initiated by a ventricular premature contraction (VPC) during the vulnerable period of cardiac repolarization. Ablation therapy for VF has been described and increasingly reported.
NOGAMI AKIHIKO, 野上 昭彦
core +1 more source
Idiopathic Intractable Diarrhoea Leading to Torsade de Pointes
An 81-year-old lady was admitted to our hospital with a 3-year history of noninfective diarrhoea and recurrent syncopal events over the last 3 months. Her initial electrocardiogram (ECG) revealed trigeminy and prolonged QTc interval.
Kyriacos Mouyis +2 more
doaj +1 more source
Predictive Analytics for Identification of Patients at Risk for QT Interval Prolongation – A Systematic Review [PDF]
Prolongation of the heart rate‐corrected QT (QTc) interval increases the risk for torsades de pointes (TdP), a potentially fatal arrhythmia. The likelihood of TdP is higher in patients with risk factors, which include female sex, older age, heart failure
Muensterman, Elena Tomaselli +1 more
core +1 more source
A Case of QT Prolongation Associated with Panhypopituitarism
We describe a 37-year-old patient with panhypopituitarism who experienced symptoms and signs of hormonal insufficiency and QT prolongation on electrocardiogram without electrolyte disturbances.
Dilek Arpaci +3 more
doaj +1 more source

