Results 81 to 90 of about 480,913 (287)
The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.Abstract Sepiapterin and its major metabolite 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) bind to distinct variants of phenylalanine hydroxylase (PAH), which converts excess phenylalanine to tyrosine, thereby stabilizing, enhancing, and prolonging PAH activity.
Lan Gao +7 more
wiley +1 more source
Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]
, 2019 Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan +6 more
core +1 more source
QTc Prolongation in Veterans With Heroin Dependence on Methadone Maintenance Treatment [PDF]
, 2015 Background: QTc prolongation and Torsade de Ppointes have been reported in patients on methadone maintenance. Objectives: In this study, QTc was compared before and after the veteran (n = 49) was on a stable dosage of methadone for 8.72 ± 4.50 years ...
Fernandez, Antony +3 more
core +2 more sources
A CASE OF METHAMPHETAMINE-INDUCED TORSADES DE POINTES [PDF]
, 2023 Michael Oriakhi, Mutsumi Kioka
openalex +1 more source
Andrology, Volume 14, Issue 1, Page 294-302, January 2026.Abstract Introduction Testosterone therapy has become a cornerstone treatment for men with hypogonadism, offering significant benefits such as improved sexual function, mood, muscle mass, and bone density. However, concerns about its cardiovascular safety have historically tempered its use.
Michael Zitzmann +15 more
wiley +1 more source
Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects. [PDF]
, 2017 AIM: The D2 /D3 antagonist amisulpride has shown promising efficacy against postoperative nausea and vomiting (PONV) at low doses. We investigated whether intravenous amisulpride has an effect on the QTc interval in a formal Thorough QT study (TQT ...
Ackerman +27 more
core +1 more source
Medicamentos que podem induzir prolongamento do intervalo QT utilizados por idosos em domicílio
Revista de Ciências Farmacêuticas Básica e Aplicada, 2015 O intervalo QT (iQT), parâmetro eletrocardiográfico, é um biomarcador não invasivo da repolarização ventricular. O aumento do iQT é uma alteração que pode ser de considerável importância clínica, pois predispõe a torsade de pointes e morte cardíaca ...
Josiane Macêdo Martins +3 more
doaj +2 more sources
Annals of Noninvasive Electrocardiology, Volume 31, Issue 1, January 2026.Sex hormones significantly influence ventricular repolarization in women treated with QT‐prolonging drugs, with estrogen prolonging and progesterone/testosterone shortening QT measures. These findings highlight a hormonal mechanism for sex‐specific arrhythmia risk and support closer monitoring of reproductive‐age women receiving QT‐prolonging therapies.
Aneliya San +11 more
wiley +1 more source
The QT interval in lightning injury with implications for the cessation of metabolism hypothesis [PDF]
An hypothesis is presented to provide an alternative to the Cessation of Metabolism hypothesis often invoked in lightning injury. Cessation of Metabolism has been proposed to explain the observation of good recovery after a prolonged period in cardiac ...
Andrews, Christopher J. +2 more
core +1 more source
Clarithromycin-Induced Long QT Syndrome: A Case Report
Case Reports in Medicine, 2012 Long QT syndrome develops for a number of reasons. The number of non-antiarrhythmic drugs reported to induce QT interval prolongation with or without torsade de pointes continues to increase.
Mecnun Cetin +4 more
doaj +1 more source