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Development of a Reverse Genetics System for Toscana Virus (Lineage A) [PDF]

Viruses, 2020
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found in the countries surrounding the Mediterranean. TOSV is an important cause of seasonal acute meningitis and encephalitis within its range. Here, we determined the full sequence of the TOSV strain 1500590, a lineage A virus obtained from an infected patient ...
Vattipally B Sreenu, Frederick Arnaud, Daniel Mair   +2 more
exaly   +7 more sources

Prevalence of Toscana virus antibodies in residents of Croatia [PDF]

Clinical Microbiology and Infection, 2012
To assess the prevalence of Toscana virus (TOSV) infection among healthy residents of Croatia we tested sera from 2016 persons, for IgG antibodies to TOSV, by an enzyme immunoassay. A total of 755 (37.5%) persons had IgG antibodies to TOSV: 53.9%, 33.6% and 6.1% among residents of the islands, coastal area and mainland of Croatia, respectively.
Bojana Mohar, Ana Jeroncic
exaly   +5 more sources

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Diagnostic tools for Toscana virus infection

Expert Review of Anti-Infective Therapy, 2011
Toscana virus (TOSV; Phlebovirus, Bunyaviridae) is an important etiological agent of acute meningitis and meningoencephalitis in Mediterranean countries. Laboratory diagnosis has been carried out in serological studies using ELISA, immunofluorescence and/or neutralization tests that are not influenced by the virus viability; however, in the acute phase
Maria Grazia Cusí, Gianni Gori Savellini   +1 more
exaly   +5 more sources

Immunoblot detection of antibodies to Toscana virus

Journal of Medical Virology, 1996
Sera from patients with sandfly fever caused by Toscana virus (TOSV) infection were tested by immunoblot for specific antibody response to TOSV derived from infected Vero-E6 cells. The 28 kDa TOSV nucleoprotein (N) was identified as the major immunodominant protein recognized by immunoblot.
T F, Schwarz, S, Gilch, C, Pauli, G, Jäger   +3 more
openaire   +2 more sources

Immunological characterization of Toscana virus proteins

Archives of Virology, 1999
The genome of Toscana virus (Bunyaviridae family, Phlebovirus genus) consists of three single stranded RNA segments (L, M, S), with negative polarity. The L and M segments contain a single ORF in viral complementary sense and the S segment contains two ORFs in "ambisense" orientation. The M segment codes for three proteins in 3'-5' genomic orientation:
P, Di Bonito, L, Nicoletti, S, Mochi, L, Accardi, A, Marchi, C, Giorgi   +5 more
openaire   +2 more sources

Toscana virus encephalitis following a holiday in Sicily

Practical Neurology, 2015
We report a case of Toscana virus encephalitis. This emerging pathogen is among the three most common causes of meningoencephalitis in Europe during the warm season, yet remains under-recognised. Doctors should consider Toscana virus infection in patients presenting with neurological symptoms who have a relevant exposure history during the summer ...
Jane C, Osborne, Elham, Khatamzas, Anjum, Misbahuddin, Rachel, Hart, Anand, Sivaramakrishnan, David P, Breen   +5 more
openaire   +2 more sources

Evidence of Toscana virus circulation in Umbria: First report

European Journal of Epidemiology, 2003
To evaluate, for the first time, circulation and clinical expression of Toscana virus (ToSv) in Umbria region we studied: (1) 93 cases of aseptic meningitis and meningoencephalitis admitted to our Department from 1989 to 2001 with negative results for common neurotropic virus; (2) 50 healthy subjects.
F Baldelli, M G Ciufolini, D Francisci
exaly   +4 more sources

Meningite da virus toscana

2008
La meningite da virus Toscana (TOSV) è un’infezione acuta di aracnoide e pia madre, a carattere benigno, causata da quest’agente, appartenente alla famiglia degli arbovirus, trasmesso all’uomo attraverso la puntura di ...
BARTOLONI, ALESSANDRO, CORTI, GIAMPAOLO
openaire   +3 more sources

Sensory polymyeloradiculopathy associated with Toscana virus infection

Journal of NeuroVirology, 2013
Sandfly viruses are arthropod-borne viruses that are endemic in the Mediterranean basin. The Toscana virus (TOSV) is the only serotype of sandfly viruses known to cause neurological symptoms in humans, usually aseptic meningitis or meningoencephalitis.
Ofer Michael, Gonen, Tzvika, Sacagiu
openaire   +2 more sources

TOSCANA VIRUS: EMERGING OR UNDERVALUED VIRUS?

2014
Objective Toscana Virus (TOSV) belongs to the Phlebovirus genus of the Bunyaviridae family; it is an arthropodborne virus transmitted to humans by Phlebotomus, Sergentomyia and Lutzomya genera, and could cause aseptic meningitis and meningoencephalitis.
Scalisi NM, Romano T, Di Franco M, Palermo CI, Franchina C, Laudani MC, Costanzo CM, Russo R, SCALIA, Guido   +8 more
openaire   +1 more source