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Development of reverse genetics for Toscana virus
Akira J. T. Alexander +8 more
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Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation. [PDF]
Gori Savellini G +4 more
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A Mediterranean Arbovirus: The Toscana Virus
Journal of Neurovirology, 2003Toscana virus (Bunyaviridae family, Phlebovirus genus) is a sandfly fever virus responsible for human neurological infections. Sandfly viruses are transmitted by insect vectors (Phlebotomus species) and the infection is present in climatic areas that allow the life cycle of the vector.
VALASSINA M., CUSI M. G., VALENSIN P.
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Diagnostic tools for Toscana virus infection
Expert Review of Anti-infective Therapy, 2011Toscana virus (TOSV; Phlebovirus, Bunyaviridae) is an important etiological agent of acute meningitis and meningoencephalitis in Mediterranean countries. Laboratory diagnosis has been carried out in serological studies using ELISA, immunofluorescence and/or neutralization tests that are not influenced by the virus viability; however, in the acute phase
CUSI M. G., GORI SAVELLINI G.
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Immunological characterization of Toscana virus proteins
Archives of Virology, 1999The genome of Toscana virus (Bunyaviridae family, Phlebovirus genus) consists of three single stranded RNA segments (L, M, S), with negative polarity. The L and M segments contain a single ORF in viral complementary sense and the S segment contains two ORFs in "ambisense" orientation. The M segment codes for three proteins in 3'-5' genomic orientation:
P, Di Bonito +5 more
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Immunoblot detection of antibodies to Toscana virus
Journal of Medical Virology, 1996Sera from patients with sandfly fever caused by Toscana virus (TOSV) infection were tested by immunoblot for specific antibody response to TOSV derived from infected Vero-E6 cells. The 28 kDa TOSV nucleoprotein (N) was identified as the major immunodominant protein recognized by immunoblot.
T F, Schwarz +3 more
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