Results 31 to 40 of about 280,100 (312)
BMC Health Services ResearchBackground Against the backdrop of increasing population aging, the uncertainty and irreversibility of climate change have a significant impact on the health and healthcare burden of the elderly.
Hongyan Yang, Yang Yang, Dequan Li
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Cost Profile of Membranes That Use Polymers of Intrinsic Microporosity (PIMs)
Membranes, 2022 Assessing the financial impact of polymers of intrinsic microporosity, otherwise known as PIMs, at the lab scale has been impeded by the absence of a holistic approach that would envelop all related financial parameters, and most importantly any indirect
Despina A. Gkika +4 more
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
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Profitability risk in conventional and organic dairy farms in São Paulo State, Brazil
Desenvolvimento em QuestãoThis study analyzed and compared the economic risks of conventional and organic milk production systems in the regions of São José do Rio Preto, Mococa, and Ribeirão Preto (SP), from January 2017 to September 2021, focusing on the probability of ...
Juliana Cristina dos Santos +1 more
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Health care and lost productivity costs of overweight and obesity in New Zealand
Australian and New Zealand Journal of Public Health, 2012 Objective: To estimate the costs of health care and lost productivity attributable to overweight and obesity in New Zealand (NZ) in 2006. Methods: A prevalence‐based approach to costing was used in which costs were calculated for all cases of disease in ...
Anita Lal +4 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
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BMJ OpenObjectives To update estimates of the health and financial burden of adverse childhood experiences (ACEs) in England and Wales and generate estimates for English regions.Design Population attributable fractions (PAFs) for ACEs were calculated for risks ...
Mark A Bellis +4 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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