Results 41 to 50 of about 280,100 (312)
Symptom-triggered detoxification using the Alcohol-Withdrawal-Scale reduces risks and health care costs [PDF]
, 2017 Aims: As there are only a few existing experimental studies on symptom-triggered therapy for patients with alcohol withdrawal, we investigated the effectiveness of symptom-triggered detoxification regarding the use and dosage of benzodiazepine and ...
Pfiffner, Luzius +9 more
core +2 more sources
Globalization and Health, 2008 Background Climate change has begun to negatively affect human health, with larger burdens projected in the future as weather patterns continue to change.
Ebi Kristie L
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Evaluating cost taxonomies for information systems management [PDF]
, 2006 The consideration of costs, benefits and risks underpin many Information System (IS) evaluation decisions. Yet, vendors and project-champions alike tend to identify and focus much of their effort on the benefits achievable from the adoption of new ...
Irani, Z +5 more
core +1 more source
Readmission risk and costs of firearm injuries in the United States, 2010-2015.
PLoS ONE, 2019 BACKGROUND:In 2015 there were 36,252 firearm-related deaths and 84,997 nonfatal injuries in the United States. The longitudinal burden of these injuries through readmissions is currently underestimated.
Sarabeth A Spitzer +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Risks in whole life cycle costs of a building [PDF]
, 2015 Diplomska naloga prikazuje postopek ocenjevanja celotnih stroškov življenjskega cikla gradbenega objekta. Pri tem so posebej izpostavljena tveganja, povezana z odločanjem, v vseh fazah življenjskega cikla gradbenega projekta, torej med zasnovo ...
Finc, Uroš
core
Total costs and budgetary effects of adaptation to climate change: An assessment for the European Union [PDF]
Adaptation to climate change is gaining increasing relevance in the public debate of climate policy. However, detailed and regionalised cost estimates as a basis for cost-benefit-analyses are rare.
Reif, Christiane, Osberghaus, Daniel
core +2 more sources