Results 91 to 100 of about 1,521,521 (318)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Maximum Number of Minimum Dominating and Minimum Total Dominating Sets

, 2013
Given a connected graph with domination (or total domination) number \gamma>=2, we ask for the maximum number m_\gamma and m_{\gamma,T} of dominating and total dominating sets of size \gamma.
Godbole, Anant, Jamieson, Jessie, Jamieson, William   +2 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Maker-Breaker total domination number

The Maker-Breaker total domination number, $γ_{\rm MBT}(G)$, of a graph $G$ is introduced as the minimum number of moves of Dominator to win the Maker-Breaker total domination game, provided that he has a winning strategy and is the first to play. The Staller-start Maker-Breaker total domination number, $γ_{\rm MBT}'(G)$, is defined analogously for the
Divakaran, Athira, James, Tijo, Klavžar, Sandi, Nair, Latha S   +3 more
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Bounds on the 2-domination number in cactus graphs [PDF]

Opuscula Mathematica, 2006
A \(2\)-dominating set of a graph \(G\) is a set \(D\) of vertices of \(G\) such that every vertex not in \(S\) is dominated at least twice. The minimum cardinality of a \(2\)-dominating set of \(G\) is the \(2\)-domination number \(\gamma_{2}(G)\).
Mustapha Chellali
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Total Roman Reinforcement in Graphs

Discussiones Mathematicae Graph Theory, 2019
A total Roman dominating function on a graph G is a labeling f : V (G) → {0, 1, 2} such that every vertex with label 0 has a neighbor with label 2 and the subgraph of G induced by the set of all vertices of positive weight has no isolated vertex.
Ahangar H. Abdollahzadeh, Amjadi J., Chellali M., Nazari-Moghaddam S., Sheikholeslami S.M.   +4 more
doaj   +1 more source

Domination parameters with number 2: interrelations and algorithmic consequences

, 2016
In this paper, we study the most basic domination invariants in graphs, in which number 2 is intrinsic part of their definitions. We classify them upon three criteria, two of which give the following previously studied invariants: the weak $2$-domination
Bonomo, Flavia, Bresar, Bostjan, Grippo, Luciano N., Milanic, Martin, Safe, Martin D.   +4 more
core