Results 101 to 110 of about 313,249 (265)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Total domination number of grid graphs
Discrete Applied Mathematics, 2002 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Lower bounds on the signed (total) $k$-domination number depending on the clique number
Communications in Combinatorics and Optimization, 2018 Let $G$ be a graph with vertex set $V(G)$. For any integer $k\ge 1$, a signed (total) $k$-dominating function is a function $f: V(G) \rightarrow \{ -1, 1\}$ satisfying $\sum_{x\in N[v]}f(x)\ge k$ ($\sum_{x\in N(v)}f(x)\ge k$) for every $v ...
L. Volkmann
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Bounds On The Disjunctive Total Domination Number Of A Tree
Discussiones Mathematicae Graph Theory, 2016 Let G be a graph with no isolated vertex. In this paper, we study a parameter that is a relaxation of arguably the most important domination parameter, namely the total domination number, γt(G).
Henning Michael A., Naicker Viroshan
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Total roman domination number of graphs
, 2022 In this paper a characterization of minimal total roman dominating functions has been proved. It has also been proved that if v is a pendant vertex and its neighbor u is not a pendant vertex then f(v) = 0 or 1 for any minimal total roman dominating function f. The operation of vertex removal has been considered.
Thakkar, Dineshbhai, Badiyani, Sanket
openaire +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source