Results 71 to 80 of about 1,145,330 (292)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Web Based Automated Total Electron Content Computation
2007 3rd International Conference on Recent Advances in Space Technologies, 2007 Total Electron Content (TEC), is widely used in monitoring ionospheric effects. TEC is expressed as the amount of free electrons within 1 m2 cross-sectional area of the region between ground and ionosphere. Although IRI and IGS analysis centers can generate and present TEC estimations, either the temporal resolution is low or estimations are based on ...
Ugurlu, Orhan +2 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Study of the TEC data obtained from the DORIS stations in relation to seismic activity
Annals of Geophysics, 2007 Ionospheric data obtained from the DORIS system are used in this paper. The DORIS system is composed of several ground-based beacons which emit at two frequencies (400 MHz and 2 GHz) and of receivers on board several satellites (currently SPOT2,
M. Parrot, F. Li
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Sensors, 2020 A new ionospheric tomography model is presented in this work. In the new model, the traditional voxel basis function is replaced by the blob basis function.
Debao Wen, Dengkui Mei, Yanan Du
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Development of Ionospheric Tomography Model Using GPS [PDF]
Journal of Astronomy and Space Sciences, 2006 We produced the electron density distribution in the ionosphere over South Korea using the data from nine permanent GPS (Global Positioning System) stations which have been operated by KASI (Korea Astronomy and Space Science Institute).
Byung-Kyu Choi +2 more
doaj +1 more source
Optimizing a sustainable ultrasound assisted extraction method for the recovery of polyphenols from lemon by-products:comparison with hot water and organic solvent extractions [PDF]
, 2018 Response surface methodology (RSM) based on a three-factor and three-level Box–Behnken design was employed for optimizing the aqueous ultrasound-assisted extraction (AUAE) conditions, including extraction time (35–45 min), extraction temperature (45–55 ...
Bowyer, Michael C. +6 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source