Results 61 to 70 of about 13,562,066 (260)

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

The influence of human milk composition and its microbiome on the gut microecology and early growth and development of preterm infants (the YI study): protocol design and cohort profile

Frontiers in Nutrition
IntroductionBreastfeeding can reduce the risk of serious illness in preterm infants. However, the influence of human milk on the gut microecology and early development of preterm infants remains unclear.MethodsThe YI Study is a prospective cohort ...
Xinyue Wang, Yan Feng, Yilan Li, Yuluyuan Tian, Simin Zhang, Jinglin Li, Jiahui Zhang, Feng Liu, Jiahe Zhou, Ting Li, Ting Li, Sufang Duan, Ignatius Man-Yau Szeto, Ignatius Man-Yau Szeto, Li Su, Xiaoqin Luo, Xiaoqin Luo   +16 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Effect of dietary Tenebrio molitor feces content on the nutrient metabolic rate of goose

Siliao yanjiu, 2021
The experiment studied the effect of dietary Tenebrio molitor feces content on the nutrient metabolic rate of goose. A total of 42 50-day-old Sichuan white male geese were randomly divided into seven groups with six replicates in each group, and one ...
Yi WEI, Yao CHEN, Dong-mei CHEN, Yun-yong LIAO, Cai-quan ZHOU   +4 more
doaj  

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Serotypes and Stx2 subtyping of Shiga toxin producing Escherichia coli isolates from cattle carcasses and feces

Revista Mexicana de Ciencias Pecuarias, 2020
Shiga toxin E. coli (STEC) is an important pathogen responsible for foodborne illness, this have been related with epidemic outbreaks in the past, mainly because of consumption of bovine meat.
Nydia Edith Reyes-Rodriguez, Jeannette Barba-León, Armando Navarro-Ocaña, Vicente Vega-Sanchez, Fabian Ricardo Gómez De Anda, Juan Martin Talavera-Gonzalez, Martin Talavera-Rojas   +6 more
doaj   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Borough of Roosevelt Historical Collection

, 1930
The Borough of Roosevelt Historical Collection documents the early 1900s history of the town, including relations with the federal government, the failure of the economic cooperatives, and the struggles of the community to survive.

core   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Bacterial profile of infant feces associated with lactation infectious breasts

, 2018
Yuko Tsunoda,1 Takashi Asahara,2 Koji Nomoto,3 Yukiko Yoshioka,4 Eisuke Fukuma1 1Department of Breast Surgery, Breast Center, Kameda Medical Center, Kamogawa, Chiba 296-8602, Japan; 2Department of Microbiological Research, Yakult Central Institute ...
Fukuma E, Tsunoda Y, Nomoto K, Asahara T, Yoshioka Y   +4 more
core