Results 221 to 230 of about 62,443 (299)

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian   +8 more
wiley   +1 more source

Postmastectomy Breast Reconstruction Following Massive Weight Loss: An Updated Systematic Review and Identification of Research Gaps

open access: yesMicrosurgery, Volume 46, Issue 2, February 2026.
ABSTRACT Background As bariatric surgery becomes increasingly common, reconstructive surgeons are encountering more massive weight loss (MWL) patients requiring breast reconstruction. MWL alters breast anatomy, tissue characteristics, and healing capacity, potentially impacting reconstructive outcomes.
Anna Paganini   +3 more
wiley   +1 more source

Efficacy and Safety of Pharmacological, Endoscopic, and Surgical Treatments for Obesity: A GRADE‐Based Network Meta‐Analysis

open access: yesObesity, Volume 34, Issue 2, Page 279-293, February 2026.
ABSTRACT Objective This review compared antiobesity strategies—obesity management medications (OMM), endoscopic bariatric procedures (EBP), and metabolic bariatric surgery (MBS)—with lifestyle intervention, placebo, or no therapy (LSI/Pbo/NT). Methods This network meta‐analysis included randomized clinical trials comparing OMM, EBP, and MBS versus LSI ...
Maurizio De Luca   +12 more
wiley   +1 more source

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

open access: yesObesity, Volume 34, Issue 2, Page 499-511, February 2026.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli   +12 more
wiley   +1 more source

Joint Pain Outcomes After Metabolic and Bariatric Surgery in Patients With and Without Hypermobility

open access: yesObesity Science &Practice, Volume 12, Issue 1, February 2026.
ABSTRACT Objective Obesity increases the risk of musculoskeletal conditions, but retrospective studies have suggested that individuals with joint hypermobility experience more joint pain after metabolic and bariatric surgery and weight loss. Joint hypermobility is the ability of one or more joints to move beyond the normal range of motion.
Elke Schubert‐Hjalmarsson   +3 more
wiley   +1 more source

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