Results 31 to 40 of about 59,421 (219)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

The Comparison of Computer Navigation and Robotic-assisted Total Knee Arthroplasty: A Review of Current Literature

Formosan Journal of Musculoskeletal Disorders
This review aimed to assess the existing evidence regarding the comparison between robotic-assisted (RA) and computer navigation (CN) total knee arthroplasty (TKA). Our study commenced on August 25, 2023, utilizing a methodological approach that combined
Chia-Chun Hsia, De-Yi Liu, Nien-En Ku, Jui-Feng Chen, Shih-Chan Hsu, Shu-Jui Kuo   +5 more
doaj   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Methods for Improving Quadriceps Femoris Strength after Total Knee Arthroplasty

Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija, 2019
Research background. The recovery of quadriceps femoris muscle strength after total knee arthroplasty is suboptimal. Quadriceps weakness is associated with decreased gait speed, balance, stair–climbing and chair rise ability, as well as increased risk ...
Toma Petkutė, Eglė Lendraitienė
doaj   +1 more source

Nontobacco Nicotine Dependence Is Associated With Perioperative Complications and Repeat Surgery After Arthroscopic Rotator Cuff Repair

Arthroscopy, EarlyView.
Purpose To compare perioperative complications and revision surgery rates between following primary rotator cuff repair among patients with nontobacco nicotine dependence (NTND), no nicotine dependence, and traditional tobacco‐related nicotine dependence.
Samuel A. Florentino, Alexander N. Berk, Logan M. Good, Jeremy M. Adelstein, Robert J. Wetzel, George Ochenjele, Joshua K. Napora   +6 more
wiley   +1 more source

Revision of the Gunston polycentric knee arthroplasty with total knee arthroplasty

Acta Orthopaedica et Traumatologica Turcica, 2020
The Gunston polycentric knee arthroplasty, first designed and performed by Frank Gunston in 1971, is the first prosthesis considering the natural knee biomechanics. Although the polycentric knee arthroplasty showed encouraging results to relieve pain and
Kaya Memisoglu, U. Sefa Muezzinoglu, Cumhur Cevdet Kesemenli   +2 more
doaj   +1 more source

Revision Total Knee Arthroplasty Using Robotic Arm Technology

Arthroplasty Today, 2022
Total knee arthroplasty (TKA) is a highly successful operation for the treatment of end-stage osteoarthritis of the knee. Increasing use of computer-assisted and robotic-assisted total joint arthroplasty has been shown to improve component position, with
Micah MacAskill, MD, Baylor Blickenstaff, MD, Alexander Caughran, MD, Matthew Bullock, DO   +3 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonist Use in Obese Patients Is Associated With Decreased Risk of Revision and Retears After Arthroscopic Rotator Cuff Repair

Arthroscopy, EarlyView.
Purpose To evaluate the impact of preoperative glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) use on medical complications, emergency department use, and orthopaedic complications in obese patients undergoing arthroscopic rotator cuff repair. Methods Obese patients (defined by relevant ICD‐10 codes and confirmed by body mass index measurements ...
Argen Omurzakov, Arsen M. Omurzakov, Robert J. Burkhart, James E. Voos, Jacob G. Calcei, John M. Apostolakos   +5 more
wiley   +1 more source

Total knee replacement in patients with osteoarthritis and concomitant inveterate patellar dislocation

Arthroplasty Today, 2019
The inveterate patellar dislocation is an uncommon entity. The most frequent findings correspond to a misaligned valgus associated with lateral patellar dislocation.
David Figueroa, MD, Alan Garín, MD, Francisco Figueroa, MD   +2 more
doaj   +1 more source

Open and Arthroscopic Acetabular Labral Reconstructions Are Associated With Improvements in Hip Patient‐Reported Outcome Measures at 1 Year, but Only an Open Approach Is Associated With Significant Reductions in Pain

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To compare initial outcomes for open versus arthroscopic acetabular labral reconstruction (ALR) using fresh meniscus allograft transplantation. Methods With informed consent, patients scheduled to undergo ALR were enrolled into a registry.
John R. Baumann, Kylee Rucinski, James L. Cook, Brett D. Crist, Cory R. Crecelius, Steven F. DeFroda   +5 more
wiley   +1 more source