Results 51 to 60 of about 7,176,390 (296)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Predicting dissatisfaction following total knee replacement:a prospective study of 1217 patients [PDF]

, 2010
Up to 20% of patients are not satisfied with the outcome following total knee replacement (TKR). This study investigated the pre- and post-operative predictors of dissatisfaction in a large cohort of patients undergoing TKR.
D. MacDonald, C. R. Howie, Scott, C E H, Scott, C. E. H., Biant, L C, MacDonald, D., Howie, C R, L. C. Biant, C. E. H. Scott, MacDonald, D; id_orcid, Biant, L. C.; id_orcid, Howie, C. R.   +11 more
core   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Perioperative safety of two-team simultaneous bilateral total knee arthroplasty in the obese patient

Journal of Orthopaedic Surgery and Research, 2010
Background Although the rates of perioperative morbidity and mortality with simultaneous bilateral total knee arthroplasty remain a concern, multiple studies have shown the procedure to be safe in selected patient populations. Evidence also remains mixed
Gaines Steven T, Mowbray John G, Dimitris Craig, Taylor Benjamin C, Steensen Robert N   +4 more
doaj   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

Advanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li, Hao Liu, Yanbin Zhu, Hang Zhang, Qifeng Tao, Wenbo Zhao, Xin Miao, Shanshan Yang, Tianyu Chen, David Hunter, Changhai Ding, Ting Wang, Juan Wang, Wei Chen   +13 more
wiley   +1 more source

The Comparison of Computer Navigation and Robotic-assisted Total Knee Arthroplasty: A Review of Current Literature

Formosan Journal of Musculoskeletal Disorders
This review aimed to assess the existing evidence regarding the comparison between robotic-assisted (RA) and computer navigation (CN) total knee arthroplasty (TKA). Our study commenced on August 25, 2023, utilizing a methodological approach that combined
Chia-Chun Hsia, De-Yi Liu, Nien-En Ku, Jui-Feng Chen, Shih-Chan Hsu, Shu-Jui Kuo   +5 more
doaj   +1 more source

Methods for Improving Quadriceps Femoris Strength after Total Knee Arthroplasty

Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija, 2019
Research background. The recovery of quadriceps femoris muscle strength after total knee arthroplasty is suboptimal. Quadriceps weakness is associated with decreased gait speed, balance, stair–climbing and chair rise ability, as well as increased risk ...
Toma Petkutė, Eglė Lendraitienė
doaj   +1 more source

Preoperative Total Iron‐Binding Capacity Is a Potential Surrogate Marker of Long‐Term Outcomes After Pancreatectomy for Pancreatic Cancer

Annals of Gastroenterological Surgery, EarlyView.
Preoperative low serum total iron‐binding capacity (TIBC) was associated with poorer overall survival and recurrence‐free survival after pancreatectomy for pancreatic cancer. These findings suggest that preoperative serum TIBC may serve as a simple surrogate marker for long‐term outcomes in patients undergoing pancreatectomy.
Taishi Yamane, Hiromitsu Hayashi, Hiroshi Sawayama, Takashi Matsumoto, Toru Takematsu, Takanobu Yamao, Yuki Kitano, Tatsunori Miyata, Hirohisa Okabe, Masaaki Iwatsuki   +9 more
wiley   +1 more source

Total knee arthroplasty 2010 [PDF]

Knee Surgery, Sports Traumatology, Arthroscopy, 2010
The Bone and Joint Decade from 2000 to 2010 has almostreached his end. The decade was invited by the UnitedNation and the World Health Organisation in order toincrease the awareness to people with musculoskeletaldiseases. The rapid increase in the prevalence of osteoar-thritis will have a growing impact on the health care andpublic health care system ...
openaire   +2 more sources

Orthobiologic Injections Adjunctive to Cartilage‐Preserving Surgery May Improve Outcomes for Focal Knee Chondral Defects: A Systematic Review of Randomized Controlled Trials With Subgroup Meta‐analyses

Arthroscopy, EarlyView.
Purpose To perform a systematic review evaluating the efficacy of orthobiologic injections as adjuncts to cartilage‐preserving surgery in improving clinical, radiographic, and histologic outcomes in adults with focal knee cartilage defects. Methods Four databases (PubMed, MEDLINE, EMBASE, and Scopus) were searched through September 2025 for randomized ...
Benjamin Blackman, Alexandru Pulbere, Seth Ybema, Marc Daniel Bouchard, Prushoth Vivekanantha, Praveen Sritharan, Darren de SA, Olufemi R. Ayeni, Jeffrey Kay   +8 more
wiley   +1 more source