Results 61 to 70 of about 125,907 (308)

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Methods for Improving Quadriceps Femoris Strength after Total Knee Arthroplasty

Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija, 2019
Research background. The recovery of quadriceps femoris muscle strength after total knee arthroplasty is suboptimal. Quadriceps weakness is associated with decreased gait speed, balance, stair–climbing and chair rise ability, as well as increased risk ...
Toma Petkutė, Eglė Lendraitienė
doaj   +1 more source

Efficacy of Continuous Passive Motion after Total Knee Arthroplasty in Veteran Patients [PDF]

, 2017
Since the early 1980s, continuous passive motion has been used as adjunct therapy in patients’ rehabilitation following total knee arthroplasty. Although existing literature challenged the benefits of continuous passive motion claiming it had no added ...
Hare, Jaimee Riza B.
core   +1 more source

Total knee arthroplasty in valgus knee

Orthopaedics & Traumatology: Surgery & Research, 2010
Total knee arthroplasty (TKA) in valgus knee has the reputation of being more difficult than in well aligned or varus knee, and there is no management consensus. Results on a continuous series of 100 TKAs on valgus knee were compared to the literature data, to define surgical strategy adapted to the various types of valgus knee.
Williot, A., Rosset, P., Favard, L., Brilhault, J., Burdin, P.   +4 more
openaire   +2 more sources

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Total knee replacement in patients with osteoarthritis and concomitant inveterate patellar dislocation

Arthroplasty Today, 2019
The inveterate patellar dislocation is an uncommon entity. The most frequent findings correspond to a misaligned valgus associated with lateral patellar dislocation.
David Figueroa, MD, Alan Garín, MD, Francisco Figueroa, MD   +2 more
doaj   +1 more source

Relationships between post operative pain management and short term functional mobility in total knee arthroplasty patients with a femoral nerve catheter: A preliminary study [PDF]

, 2011
Background: Effective pain management following total knee arthroplasty (TKA) is fundamental in achieving positive rehabilitation outcomes. The purpose of our study was to investigate post operative pain management in relation to short term functional ...
Fetherston, C., Ward, S.
core   +3 more sources

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Simultaneous bilateral total knee arthroplasty

Acta Orthopaedica et Traumatologica Turcica, 2021
Total knee arthroplasty is a treatment procedure which reliefs pain, corrects deformity, improves functions for the patients whose have gonarthrosis which are unresponsive to conservative therapy.
Sukru Arac, Hakan Boya, Ozal Ozcan
doaj  

Preoperative Total Iron‐Binding Capacity Is a Novel Surrogate Marker of Short‐ and Long‐Term Outcomes After Liver Resection for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
HCC patients with low preoperative TIBC levels experienced significantly more frequent post‐hepatectomy complications. Furthermore, these patients were significantly correlated with worse survival. Preoperative serum TIBC levels may be a novel surrogate marker of postoperative complications and long‐term survival after hepatectomy.
Taishi Yamane, Hiromitsu Hayashi, Daisuke Ogawa, Shotaro Kinoshita, Yuta Shiraishi, Takanobu Yamao, Yuki Kitano, Tatsunori Miyata, Hirohisa Okabe, Masaaki Iwatsuki   +9 more
wiley   +1 more source