Results 141 to 150 of about 38,997 (270)

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Editorial: Alignment options and robotics in total knee arthroplasty (TKA) "Alignment, alignment, alignment, but TKA fail mainly for infections and instability". [PDF]

Front Surg, 2023
Indelli PF, Salvi AG, Petralia G.
europepmc   +1 more source

Distal femoral morphology as a risk factor for osteoarthritis

The Anatomical Record, Volume 309, Issue 5, Page 1394-1405, May 2026.
Abstract Osteoarthritis (OA) is a leading cause of disability affecting millions of adults in the United States, commonly resulting in the need for total knee arthroplasty (TKA) to restore mobility and quality of life. This study investigates potential differences in baseline distal femoral shape between individuals who received TKA due to OA and a ...
Haley Horbaly
wiley   +1 more source

Bilateral Total Hip and Right Knee Arthroplasty in a Sickle Cell Disease Patient with Multiple Joint Osteonecrosis: A Case Report and Literature Review

Nigerian Postgraduate Medical Journal
Sickle cell disease is an autosomal recessive genetic disorder with the underlying pathology, resulting in sickling of the red blood cells in deoxygenated conditions.
Michael Ebiyon Ugbeye, Kehinde Adesola Alatishe, Chukwuebuka Okezie   +2 more
doaj   +1 more source

Arterial Complications following Total Knee Arthroplasty (TKA): A Systematic Review and Proposal for Improved Monitoring. [PDF]

Malays Orthop J, 2023
Hodgson H, Saghir N, Saghir R, Coughlin P, Scott D, Howard A.   +5 more
europepmc   +1 more source

EEG‐Based Cortical Alterations in Patients Following Total Hip and Knee Arthroplasty Due to Osteoarthritis: Pre‐ and Post‐Operative Assessment

Brain and Behavior, Volume 16, Issue 5, May 2026.
This study reveals significant neuroplastic changes in cortical EEG activity post total hip/knee arthroplasty in osteoarthritis patients, with increased low alpha and theta power over frontocentral/parietal regions during rest and motor imagery. These alterations accompany functional improvements (HHS/KSS), suggesting qEEG's potential for monitoring ...
Pawel Piotr Dobrakowski, Jaroslaw Szyszka   +1 more
wiley   +1 more source

Retracted: Effect of Early Electroacupuncture Combined with Enhanced Recovery after Surgery (ERAS) on Pain Perception and Dysfunction in Patients after Total Knee Arthroplasty (TKA). [PDF]

Biomed Res Int, 2023
International BR.
europepmc   +1 more source

Robotic arm‐assisted total knee arthroplasty reduces postoperative inflammatory response and blood loss compared to manual total knee arthroplasty: A matched‐pairs analysis of 688 patients

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 5, Page 1691-1699, May 2026.
Abstract Purpose Robotic arm‐assisted total knee arthroplasty (raTKA) has demonstrated several advantages over manual TKA (mTKA), including enhanced early recovery. Reduced soft tissue trauma and avoidance of femoral intramedullary canal opening have been hypothesised to lower the systemic inflammatory response.
Dirk Müller, Igor Lazic, Benjamin Schloßmacher, Vincent Lallinger, Michael T. Hirschmann, Rüdiger von Eisenhart‐Rothe, Florian Pohlig   +6 more
wiley   +1 more source

Fulfilment of patients' mandatory expectations are crucial for satisfaction: a study amongst 352 patients after total knee arthroplasty (TKA). [PDF]

Knee Surg Sports Traumatol Arthrosc, 2023
Lützner C, Beyer F, David L, Lützner J.   +3 more
europepmc   +1 more source

Comparable outcomes and early revision rates between restricted and unrestricted functional knee positioning in robotic‐assisted total knee arthroplasty for varus deformities ≥10°

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 5, Page 1682-1690, May 2026.
Abstract Purpose Functional knee positioning (FKPos) in total knee arthroplasty (TKA) optimises outcomes by balancing individual anatomical and soft tissue characteristics. Managing marked varus deformity presents challenges in achieving balance when tibial alignment is restricted to 3° of varus, necessitating either medial soft tissue release or ...
Christos Koutserimpas, Konstantinos Dretakis, Enejd Veizi, Nevzat Arıcan, Elvire Servien, Cécile Batailler, Sébastien Lustig   +6 more
wiley   +1 more source