Results 231 to 240 of about 171,596 (303)

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Extracellular Vesicle‐Mediated Communication Between Anterior Cruciate Ligament and Bone Marrow Cells Modulates Hamstring Tenocyte Behavior and Apoptosis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo   +5 more
wiley   +1 more source

Three in every four systematic reviews and meta‐analyses on concomitant anterior cruciate ligament reconstruction and anterolateral complex procedures present at least one type of spin in the abstract

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Spin is a form of bias that misrepresents research findings, potentially influencing clinical decisions and patient care. This meta‐research study evaluates the prevalence and types of spin in abstracts of systematic reviews and meta‐analyses comparing anterior cruciate ligament reconstruction (ACLR) with and without lateral extra ...
Adela Gottardi   +5 more
wiley   +1 more source

Increased reoperation rates after meniscus repair compared to arthroscopic partial meniscectomy: Data from a comprehensive clinical cohort with up to 10 years follow‐up

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To investigate the rates of knee reoperation and medical complications after meniscal repair versus partial meniscectomy (APM) up to 10 years after surgery. Methods All patients ≥ 15 years old operated for a meniscal tear with meniscus repair or partial meniscectomy at Scania University Hospital were included, between year 2010 and ...
Fredrik Boric‐Persson   +3 more
wiley   +1 more source

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