Results 51 to 60 of about 16,729 (267)

The prognostic value of baseline 18FDG – Positron Emission Tomography – Computed Tomography in cervical cancer patients treated with definitive chemoradiotherapy – External multicentre validation model

Physics and Imaging in Radiation Oncology
Background and purpose: 18F-Fluorodeoxyglucose-Positron Emission Tomography – Computed Tomography (18FDG-PET-CT) is commonly used for baseline clinical staging in cervical cancer.
Emilia Staniewska, Magdalena Stankiewicz, Ewa Burchardt, Karolina Grudzien, Katarzyna Raczek-Zwierzycka, Justyna Rembak-Szynkiewicz, Matylda Sobczak, Andrea d’Amico, Damian Borys, Izabela Gorczewska, Kamil Krysiak, Martin Rydzinski, Rafal Stando, Mateusz Spalek, Zuzanna Nowicka, Rafal Tarnawski, Marcin Miszczyk   +16 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Prognostic Value of Total Lesion Glycolysis and Metabolic Tumor Volume in Non-Small Cell Lung Cancer

Annals of Oncology, 2014
Aim: To predict the outcome of patients with NSCLC the currently used prognostic system (TNM) is not accurate enough.The prognostic significance of SUV measured by PET remains controversial. This retrospective study aims to evaluate the prognostic value in overall survival (OS) and progression free survival (PFS) of the standard uptake value(SUV ...
Vanhove, Karolien, Heylen, Micheline, Derwael, Ruben, Louis, Evelyne, Thomeer, Michiel, Mesotten, Liesbet, Adriaensens, Peter, Boellaard, Ronald   +7 more
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Prognostic Value of Dual-Time-Point ¹⁸F-Fluorodeoxyglucose PET/CT in Metastatic Breast Cancer: An Exploratory Study of Quantitative Measures

Diagnostics, 2020
This study aimed to compare the prognostic value of quantitative measures of [18F]-fluorodeoxyglucose positron emission tomography with integrated computed tomography (FDG-PET/CT) for the response monitoring of patients with metastatic breast cancer (MBC)
Mohammad Naghavi-Behzad, Charlotte Bjerg Petersen, Marianne Vogsen, Poul-Erik Braad, Malene Grubbe Hildebrandt, Oke Gerke   +5 more
doaj   +1 more source

Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy [PDF]

Clinical Nuclear Medicine, 2017
In the context of oropharyngeal cancer treated with definitive radiotherapy, the aim of this retrospective study was to identify the best threshold value to compute metabolic tumor volume (MTV) and/or total lesion glycolysis to predict local-regional control (LRC) and disease-free survival.One hundred twenty patients with a locally advanced ...
Crevoisier, Renaud, De, Bourhis, Jean, Prior, John O., Castelli, Joël, Depeursinge, Adrien, de Bari, Berardino, Devillers, Anne   +6 more
openaire   +4 more sources

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source