Results 51 to 60 of about 379,174 (254)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Long-term lung function trajectories in Swedish COVID-19 ICU survivors: a two-year follow-up study

European Clinical Respiratory Journal
Introduction Longitudinal studies of lung function following COVID-19 remain limited. This study examined lung function in COVID-19 patients for two years after discharge from an intensive care unit (ICU).Methods Patients treated for COVID-19 in Uppsala ...
Marta A. Kisiel, Emil Ekbom, Christer Janson, Össur Emilsson, Miklos Lipcsey, Robert Frithiof, Michael Marks-Hultström, Andrei Malinovschi   +7 more
doaj   +1 more source

PERBEDAAN KAPASITAS FUNGSI PARU PEKERJA TAMBANG BATUBARA ANTARA SHIFT SIANG DAN MALAM

Berkala Kedokteran, 2015
The capacity of lung function (FEV1%) is the volume of air expelled in the first second. Impairment of lung function capacity coal miners can be caused by shift work.
Nadia Bunga Kalistra, Qomariyatus Sholihah, Nurul Hidayah   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Faal Paru Statis [Static Lung Function]

Jurnal Respirasi, 2016
Respiration or breathing is the body’s attempt to meet the needs of O2 in the metabolic process and emit CO2 as a result of intermediary metabolism by lung and respiratory organs together so that the resulting cardiovascular oxygen rich blood ...
Arief Bakhtiar, Wirya Sastra Amran
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A supervised exercise program and regular care in upper limb disability and lung capacity in patients with breast cancer undergoing radiotherapy: a randomized clinical trial

Revista Pesquisa em Fisioterapia
BACKGROUND: Breast cancer is a disease in which the cells present in the breast grow abnormally.  Musculoskeletal problems and breathing problems are common following breast cancer surgeries.
Parul Dalal, Neha Sharma, Sunita Sharma
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Uma análise entre índices pressóricos, obesidade e capacidade cardiorrespiratória em escolares Comparison analysis of blood pressure, obesity, and cardio-respiratory fitness in schoolchildren

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: Durante a infância e adolescência, o sedentarismo, o excesso de peso e a alimentação inadequada são fatores de risco para doenças crônicas, sobretudo obesidade, hipertensão arterial sistêmica e diabete melito.
Miria Suzana Burgos, Cézane Priscila Reuter, Leandro Tibiriçá Burgos, Hildegard Hedwig Pohl, Liane Teresinha Schuh Pauli, Jorge André Horta, Miriam Beatris Reckziegel, Silvia Isabel Rech Franke, Daniel Prá, Marcelo Camargo   +9 more
doaj