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The Development of Total Parenteral Nutrition

The American Surgeon™, 2017
The first patient to receive complete nourishment of a patient by intravenous infusion independent of the alimentary tract was an infant girl born with near-total small bowel atresia. Total parenteral nutrition, the intravenous infusion of nutrients, has been attempted since Harvey's description of the circulatory system in the early 17th century.
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A Total Parenteral Nutrition Protocol

Drug Intelligence & Clinical Pharmacy, 1977
The need for guidelines on the use of concentrated nutritional solutions to achieve effective total parenteral nutrition has become very evident in our hospitals. As these are teaching hospitals, our physicians write TPN orders for short-term surgical patients, long-term patients (home TPN), burn patients, neonatal patients and selected cancer patients.
J P, Swenson   +4 more
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Total Parenteral Nutrition in Malignancy

Annals of Internal Medicine, 1985
Excerpt To the editor: Shike and associates (1) showed that when total parenteral nutrition is used unnecessarily it raises the cost of medical care and prolongs hospitalization without correspondi...
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Postoperative Total Parenteral Nutrition

World Journal of Surgery, 1999
Abstract.Surgical trauma induces complex physiologic changes that lead to catabolism and loss of body cell mass. This reaction is usually mild but can be exacerbated by previous malnutrition and postoperative complications. To avoid severe metabolic distress, nutritional therapy may be prescribed, using the enteral route whenever possible ...
D L, Waitzberg, C, Plopper, R M, Terra
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Guidelines for Total Parenteral Nutrition

JAMA: The Journal of the American Medical Association, 1972
Total parenteral nutrition is a procedure capable of maintaining patients in good condition for prolonged periods while underlying disease is being treated. Achievement of this goal presents problems in formulation, in sterile preparation, and in safe administration of the nutrient solution.
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Total parenteral nutrition

Postgraduate Medicine, 1990
Delivery of total parenteral nutrition (TPN) is a complex procedure requiring a basic knowledge of nutritional physiology and an understanding of the impact of various disease states on utilization of nutrient substrates. The goals of TPN are to reverse catabolism, promote anabolism, and build structural protein.
S A, McClave   +3 more
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TOTAL PARENTERAL NUTRITION AND CHOLESTASIS

Clinics in Liver Disease, 1999
Hepatobiliary dysfunction is recognized as a major adverse effect of total parenteral nutrition (TPN). It is unknown if this is caused by a deficiency or toxicity of the TPN solution or the underlying pathophysiology of disease processes that require TPN therapy.
I S, Sandhu, C, Jarvis, G T, Everson
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Total Parenteral Nutrition in Adults

AJN, American Journal of Nursing, 1978
Parenteral hyperalimentation is the intravenous delivery of essential nutrients to maintain a patient in positive nitrogen balance and nutritional equilibrium. It is indicated when gastrointestinal intake is impossible, potentially hazardous, or insufficient(1).
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Cholestasis Induced by Total Parenteral Nutrition

Clinics in Liver Disease, 2008
Parenteral nutrition is a life-saving treatment for patients who have acute and chronic intestinal failure. Severe cholestasis induced by total parental nutrition (TPN-IC) is characterized by bile duct regeneration, portal inflammation, and fibrosis.
Guglielmi F. W.   +9 more
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