Results 41 to 50 of about 50,370 (258)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Numerical Analysis of the Effect of S-Shaped Duct Key Geometry Parameters on the Inlet Distortion of Distributed Ducted Fans

Aerospace
Distributed propulsion systems are strategically placed along the aircraft wingspan to ingest the fuselage boundary layer, thereby enhancing propulsion efficiency.
Wei Jia, Guanghui Li, Tao Liu, Qingguo Kong, Shuiting Ding   +4 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Potential Propulsive and Aerodynamic Benefits of a New Aircraft Concept: A Low-Speed Experimental Study

Aerospace, 2023
The aerodynamic design of a new aircraft concept was investigated through subsonic wind-tunnel testing using 1:28-scale powered models. The aircraft configuration integrates a box-wing layout with engines located at the rear part of the fuselage ...
Pedro D. Bravo-Mosquera, Hernán D. Cerón-Muñoz, Fernando M. Catalano   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Study on the Effects of Inflow Conditions on the Inlet Performance of a Dorsal S-Shaped Inlet

Aerospace
As an important aerodynamic configuration of the new-generation UAV, the dorsal S-shaped inlet’s performance is affected by the complex coupling of inflow conditions and the boundary layer ingestion effect.
Meng Cao, Daxin Liao, Hexiang Wang, Neng Xiong, Fangji Li, Dawei Liu, Ce Zhang, Jie Chen, Yang Tao   +8 more
doaj   +1 more source

Improving the efficiency of a serpentine inlet duct by using of Blowing Jet Vortex Generators flow control technique [PDF]

مجله مدل سازی در مهندسی, 2018
In this research, aerodynamic performance of a double s-shaped serpentine inlet duct is numerically investigated by using of blowing Jet vortex generators flow control technique.
iman Maghsoudi, mostafa mahmoodi, mohammad ali vaziri zanjani   +2 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Investigation of Flow Control in an Ultra-Compact Serpentine Inlet with Fluidic Oscillators

Aerospace
For optimal aerodynamic efficiency of specific ultra-compact serpentine intake, fluid oscillators are utilized to regulate airflow. This study employs advanced numerical simulation techniques to examine the effects of various control positions, jet ...
Lei Liu, Maolong Bai, Zhihao Wang, Zhengkang Lin, Kun Wang, Huijun Tan, Ziyun Wang   +6 more
doaj   +1 more source