Results 71 to 80 of about 10,312,408 (276)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Quarterly report of Connecticut Resources Recovery Authority operations for the quarter ending ...; Quarterly report of CRRA operations for the quarter ending ...

open access: yes, 2009
Quarterly; Began with Mar. 31, 2004?; Description based on: Mar. 31, 2004; title from foot of p. 1 (publisher's web site, viewed Nov. 19, 2008).; Latest issue consulted: June 30, 2008 (viewed Nov.
Connecticut Resources Recovery Authority.
core   +4 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Parameter Optimization of Jet Control for Compression Ramps of Two-DimensionalInlet Based on Isight

open access: yes气体物理
Two-dimensional inlet is usually used in the wide-speed-range aircraft which has a higher flying velocity region. It is difficult to meet more requirements under both low-speed and high-speed flow conditions.
Fengtao SUN   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Significant intra-valvular pressure loss across EPIC SUPRA and perimount magna supra-annular designed aortic bioprostheses in patients with normal aortic size

open access: yesIndian Heart Journal, 2017
Doppler-derived trans-prosthetic gradients are higher and the estimated effective valve area is smaller than the catheter-derived and directly measured hemodynamic values, mostly due to pressure recovery phenomenon.
Jagdish C. Mohan   +3 more
doaj   +1 more source

Flow performance comparison along the centerline in straight and s shaped diffuser

open access: yesJournal of Thermal Engineering, 2020
In this paper of the S shaped diffuser with area ratio (AR) 1.5, an experimental investigation was conducted to a nalyze the effect of the change in curvature of a straight wall diffuser.
Hardial SİNGH
doaj   +1 more source

Recovery From Alcohol and Other Drug Problems in the U.S. Population: Prevalence, Pathways, and Predictors [PDF]

open access: yes, 2018
The concept of "recovery" has become the organizing paradigm in many middle and high income countries globally with a goal of orienting services in cost effective ways to help sufferers achieve and maintain long term remission. Despite this focus, little
Hoeppner, Bettina   +5 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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