Results 81 to 90 of about 512,638 (310)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Effects of cage culture on dissolved inorganic nutrient and surface sediment composition in Sulaman Bay Lagoon, Sabah, Malaysia [PDF]

open access: yes, 2014
The major nutrient inputs into Sulaman Bay lagoon are wastes from a nearby village together with particulate organic matter and surface sediment as runoff from mangrove area, as well as from aquaculture activities. The main objective of this study was to
Abentin Estim   +2 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Application of SWAT Model for Sediment Loads from Valleys Transmitted to Haditha Reservoir

open access: yesJournal of Engineering, 2016
This study included the extraction properties of spatial and morphological basins studied using the Soil and Water Assessment Tool (SWAT) model linked to (GIS) to find the amount of sediment and rates of flow that flows into the Haditha reservoir .
Ayad Sleibi Mustafa, Ass. Prof. Dr.   +2 more
doaj  

Monitoring Polycyclic Aromatic Hydrocarbon Concentrations in Austin, TX, After the Coal-Tar Sealant Ban [PDF]

open access: yes, 2012
Polycyclic Aromatic Hydrocarbons (PAH) are a group of chemicals consisting of three or more fused benzene rings. Many of this group of compounds are considered Toxic Pollutants and listed as Priority Pollutants by the EPA.
Richter, Aaron
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Mercury in sediments and pore waters at a contaminated site in the Tagus estuary

open access: yesCiencias Marinas, 2003
 Two sediment cores were collected at a contaminated site of the North Channel in the Tagus estuary. Sediments were sliced in 1 to 2-cm vertical sections.
J Canário, C Vale, M Caetano
doaj   +1 more source

A new molecular diagnostic tool for surveying and monitoring Triops cancriformis populations [PDF]

open access: yes, 2017
© 2017 Sellers et al. The tadpole shrimp, Triops cancriformis, is a freshwater crustacean listed as endangered in the UK and Europe living in ephemeral pools.
Griffin, Larry R.   +3 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Water Quality Sampling, Analysis and Annual Load Determinations for TSS, Nitrogen and Phosphorus at the Washington County Road 195 Bridge on the West Fork of the White River, 2004 Annual Report [PDF]

open access: yes, 2005
A water quality sampling station was installed at the Washington County road 195 bridge on the West Fork of the White River just above the confluence of the three main forks of the Upper White River in December 2001.
Cash, L. Wade   +3 more
core   +2 more sources

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