Results 61 to 70 of about 1,105,104 (309)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Extractable nitrogen and microbial community structure respond to grassland restoration regardless of historical context and soil composition. [PDF]

, 2015
Grasslands have a long history of invasion by exotic annuals, which may alter microbial communities and nutrient cycling through changes in litter quality and biomass turnover rates.
Allen, Edith B, Crowley, David, Dickens, Sara Jo M, Santiago, Louis S   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Mediating role of work⁃family conflict between work stress and turnover intention among nurses

Huli yanjiu, 2020
ObjectiveTo explore the mediate role of work⁃family conflict between work stress and turnover intention among nurses.MethodsA total of 2 303 registered female nurses from 11 tertiary grade A hospitals in three regions of Hubei province,were recruited by ...
YANG Tiantian, LI Xiaoyan, YU Liping, LI Yili, LI Shiyue, YAN Hong   +5 more
doaj  

PENGARUH TOTAL ASSET TURNOVER, LEVERAGE DAN PROFITABILITAS TERHADAP FINANCIAL DISTRESS

COMPETITIVE Jurnal Akuntansi dan Keuangan, 2021
Tujuan dari penelitian ini untuk mengetahui pengaruh total asset turnover, leverage dan profitabilitas terhadap financial distress pada perusahaan sub sektor property dan real estate yang terdaftar di Bursa Efek Indonesia (BEI). Periode waktu penelitian yang digunakan adalah 5 tahun yaitu periode 2015-2019.Populasi penelitian ini meliputi seluruh ...
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Psychological contract and turnover intention among healthcare assistants in a hospital environment: a multi-center cross-sectional analysis

Frontiers in Psychology
AimThe aim of this study was to examine the correlation between psychological contract and turnover intention among hospital healthcare assistants.DesignA multi-center cross-sectional analysis was employed in this study.MethodsA survey was conducted ...
Jing-ping Yang, Feng Xue, Lin Zhang, Qiaoxian Zhang   +3 more
doaj   +1 more source

Pengaruh Biaya, Produktivitas Aktiva dan Struktur Modal dalam Meningkatkan Profitabilitas Perusahaan

Binus Business Review, 2010
This study examined the effect of cost, productivity of assets and capital structure of an automotive company's profitability. This study focuses on the productivity of assets which include factors such as operating leverage, sales, inventory turnover ...
Muhammad Yusuf
doaj   +1 more source

PENGARUH MODAL KERJA TERHADAP RETURN ON INVESTED CAPITAL PADA PERUSAHAAN TEKSTIL DAN GARMENTYANG TERDAFTAR DI BURSA EFEK INDONESIA [PDF]

, 2015
Teuku Chris Adhiatma, 2015: The Influence ofworking capital on return on invested capital of listed textile and garment companies in Indonesia Stock Exchange. Thesis. Department of Accounting Faculty of Economic, State University of Jakarta.
ADHIATMA, TEUKU CHRIS
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source