Results 171 to 180 of about 5,912,595 (286)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Joint total variation-based reconstruction of multiparametric magnetic resonance images for mapping tissue types. [PDF]

NMR Biomed, 2021
Pandey S, Snider AD, Moreno WA, Ravi H, Bilgin A, Raghunand N.   +5 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Improved Ultrasound Microvessel Imaging Using Deconvolution with Total Variation Regularization. [PDF]

Ultrasound Med Biol, 2021
Lok UW, Trzasko JD, Huang C, Tang S, Gong P, Kim Y, Lucien F, Lowerison MR, Song P, Chen S.   +9 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Predicting human detection performance in magnetic resonance imaging (MRI) with total variation and wavelet sparsity regularizers. [PDF]

Proc SPIE Int Soc Opt Eng, 2022
O'Neill AG, Lingala SG, Pineda AR.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Directional adaptive mode total variation for seismic data denoising. [PDF]

Sci Rep
Banjade TP, Zhou C, Yang Y, Li H, Deng J.   +4 more
europepmc   +1 more source

The Impact of Total Variation Regularized Expectation Maximization Reconstruction on ⁶⁸Ga-DOTA-TATE PET/CT Images in Patients With Neuroendocrine Tumor. [PDF]

Front Med (Lausanne), 2022
Liu L, Liu H, Xu S, Zhang S, Tao Y, Mok GSP, Chen Y.   +6 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source