Results 251 to 260 of about 17,556,704 (381)

Association between variations in the gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol-8

, 2011
Melanie Kolz, Baumert Jens, Müller Martina, Natalie Khuseyinova, Klopp Norman, Barbara Thorand, Meisinger Christine, Herder Christian, Koenig Wolfgang, Thomas Illig   +9 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A nonlinear total variation based computed tomography (CT) image reconstruction method using gradient reinforcement. [PDF]

PeerJ
Ertas M.
europepmc   +1 more source

Impact of total variation regularized expectation maximization reconstruction on the image quality of ⁶⁸Ga-PSMA PET: a phantom and patient study. [PDF]

Br J Radiol, 2021
Yang FJ, Ai SY, Wu R, Lv Y, Xie HF, Dong Y, Meng QL, Wang F.   +7 more
europepmc   +1 more source

A STUDY OF VARIATION OF TOTAL LEUCOCYTE COUNT AND PLATELET COUNT WITH DIFFERENT PHASES OF MENSTRUAL CYCLE

, 2019
Munagavalasa Ratna Deepti, Uma Valivety
openalex   +1 more source

Acoustic- and elastic-waveform inversion using a modified total-variation regularization scheme [PDF]

, 2014
Youzuo Lin, Lianjie Huang
openalex   +1 more source

Discrete Total Variation: New Definition and Minimization

SIAM Journal of Imaging Sciences, 2017
Laurent Condat
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sparse-view x-ray CT reconstruction via total generalized variation regularization

, 2014
Shanzhou Niu, Yang Gao, Zhaoying Bian, Jing Huang, Wufan Chen, Gaohang Yu, Zhengrong Liang, Jianhua Ma   +7 more
openalex   +1 more source