Results 71 to 80 of about 8,022 (261)

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

ON TOTALLY UMBILICAL SUBMANIFOLDS OF SOME CLASS RIEMANNIAN MANIFOLDS

Demonstratio Mathematica, 1983
The authors study totally umbilical submanifolds M with parallel mean curvature vector in pseudo-Riemannian manifolds N, such that the curvature tensor R of M satisfies \(R(X,Y)\cdot R=0\), while N carries a generalized curvature tensor \(\tilde T\) with \(\tilde R\)(X,Y)\(\cdot \tilde T=0\), \(\tilde R\) being the curvature of N.
Adamów, Adam, Deszcz, Ryszard
openaire   +2 more sources

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Heat‐Suppressing Projection Two‐Photon Lithography Enables High‐Throughput Sub‐Micrometer Manufacturing of Biopolymer Hydrogels for Tissue Engineering

Advanced Science, EarlyView.
The iLEAP technique integrates high‐throughput two‐photon lithography with extrusion printing, bridging sub‐micrometer precision and macroscopic scaffold fabrication. By employing a low‐exothermic photoinitiator, it mitigates thermal damage to biopolymers and preserves bioactivity.
Qifeng Guan, Yanzhe Fu, Xiangyu Xu, Naitao Li, Sen Hou, Kai Wang, Yufan Wang, Jiakun Li, Ping Li, Jiebo Li, Lizhen Wang, Yubo Fan   +11 more
wiley   +1 more source

Ricci Solitons on Riemannian Hypersurfaces Generated by Torse-Forming Vector Fields in Riemannian and Lorentzian Manifolds

Axioms
In this paper, we examine torse-forming vector fields to characterize extrinsic spheres (that is, totally umbilical hypersurfaces with nonzero constant mean curvatures) in Riemannian and Lorentzian manifolds.
Norah Alshehri, Mohammed Guediri
doaj   +1 more source

Noninvariant Hypersurfaces of a Nearly Trans-Sasakian Manifolds

Journal of Mathematics, 2014
The present paper focuses on the study of noninvariant hypersurfaces of a nearly trans-Sasakian manifold equipped with (f,g,u,v,λ)-structure. Initially some properties of this structure have been discussed.
Satya Prakash Yadav, Shyam Kishor
doaj   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Spectral characterization and Schrödinger operator of space-like submanifolds

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2015
In this paper, we would like to study space-like submanifolds in a de Sitter spaces Spn+p(1). We define and discuss three Schrödinger operators LH, LR, LR/H and obtain some spectral characterizations of totally umbilical space-like submanifolds in terms ...
Shu Shichang, Zhu Tianmin
doaj   +1 more source

Conformal quasi-hemi-slant $\xi^{\perp}$-Riemannian submersions from Sasakian manifolds [PDF]

Mathematica Bohemica
We introduce some geometric properties of a horizontally conformal quasi-hemi-slant Riemannian submersion from a Sasakian manifold, normal to the characteristic vector field, supported by an example.
Fortuné Massamba, Pontsho Moile
doaj   +1 more source