Results 71 to 80 of about 7,865 (260)

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

TOTALLY UMBILICAL CR-SUBMANIFOLDS OF A NEARLY KAEHLER MANIFOLD

Tamkang Journal of Mathematics, 1996
The geometry of a CR-submanifold in a Kaehler manifold has been extensively studied. B.Y . Chen has classified the totally umbilical CR-submanifolds of a Kaehler manifold and showed that they are either totally geodesic, or totally real or dim$(D^{\perp}) =1$. In this paper we show that such a result is also true in a nearly Kaehler manifold.
Kon, S. H., Tan, Sin-Leng
openaire   +3 more sources

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Ricci Solitons on Riemannian Hypersurfaces Generated by Torse-Forming Vector Fields in Riemannian and Lorentzian Manifolds

Axioms
In this paper, we examine torse-forming vector fields to characterize extrinsic spheres (that is, totally umbilical hypersurfaces with nonzero constant mean curvatures) in Riemannian and Lorentzian manifolds.
Norah Alshehri, Mohammed Guediri
doaj   +1 more source

Noninvariant Hypersurfaces of a Nearly Trans-Sasakian Manifolds

Journal of Mathematics, 2014
The present paper focuses on the study of noninvariant hypersurfaces of a nearly trans-Sasakian manifold equipped with (f,g,u,v,λ)-structure. Initially some properties of this structure have been discussed.
Satya Prakash Yadav, Shyam Kishor
doaj   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Conformal quasi-hemi-slant $\xi^{\perp}$-Riemannian submersions from Sasakian manifolds [PDF]

Mathematica Bohemica
We introduce some geometric properties of a horizontally conformal quasi-hemi-slant Riemannian submersion from a Sasakian manifold, normal to the characteristic vector field, supported by an example.
Fortuné Massamba, Pontsho Moile
doaj   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Spectral characterization and Schrödinger operator of space-like submanifolds

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2015
In this paper, we would like to study space-like submanifolds in a de Sitter spaces Spn+p(1). We define and discuss three Schrödinger operators LH, LR, LR/H and obtain some spectral characterizations of totally umbilical space-like submanifolds in terms ...
Shu Shichang, Zhu Tianmin
doaj   +1 more source