Results 111 to 120 of about 512,873 (305)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
ELT Worldwide: Journal of English Language TeachingThis research delves into an examination of the language styles employed by tour guides in Huta Siallagan when interacting with international tourists. The primary objectives of this study were twofold: first, to categorize and identify the various types
Sabrina Anjelina Siburian +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
The Most Anagrammatic Capital? [PDF]
, 1992 Caren is acting as a tour guide for Tomas, a visitor to a certain state capital. Its letters can be repeatedly rearranged to fill the blank spaces in the dialogue below with appropriate phrases. Can you complete their conversation?
Dennison, Mary Lois
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Politics and Canon of Audience: Tourists and Local Cultural Performances [PDF]
, 2008 Tourists become important audience of traditional performing arts in Ubud. Crossing through several boundaries created by agents of tourism, from tour leader to local guide, hotel crew to hawker, not only the tourists, the audience but even the ...
Shiva, Rijal
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
GuideBot. A Tour Guide System Based on Mobile Robots
International Journal of Advanced Robotic Systems, 2013 There is a growing interest in the use of tour guide mobile robots in different environments such as museums, exhibitions and fairs. This type of robot should have autonomy, robust perception and navigation systems, and should also be oriented towards ...
Joaquín López +3 more
doaj +1 more source
How to Form Wellbeing Perception and Its Outcomes in the Context of Elderly Tourism: Moderating Role of Tour Guide Services. [PDF]
Int J Environ Res Public Health, 2020 Hwang J, Kim JJ, Lee JS, Sahito N.
europepmc +1 more source