Results 121 to 130 of about 512,873 (305)
Book review: networks of New York: an internet infrastructure field guide by Ingrid Burrington [PDF]
, 2017 In Networks of New York: An Internet Infrastructure Field Guide, Ingrid Burrington takes readers on an illustrated tour of the material objects and networks of New York City upon which internet provision depends, from road markings to manhole covers and ...
Shaw, Joe
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Designing a Travel Guide to the Un-Natural World: Exploring a Design-led Methodology [PDF]
, 2009 The analogy of designer as tourist in the un-natural world is used as an aid for thinking my way into the nature of design research. An exploration of how the design researcher, like a tourist, travels widely through the un-natural world of thought ...
Hocking, Viveka Turnbull
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Automatic Presentations Generation Based on Patterns for Tour-Guide Robots [PDF]
, 2008 This paper proposes an automatic presentation generation for a tour-guide robot making use of natural language processing and patterns. To reach a suitable approximation in a believable presentation some parameters are identified and described in this ...
Galán López, Ramón +2 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
International Research Journal of Modernization in Engineering Technology and Science, 2023 openaire +1 more source