Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Pieces of Iowa’s Past, February 15, 2012 [PDF]
Pieces of Iowa’s Past, published by the Iowa State Capitol Tour Guides weekly during the legislative session, features historical facts about Iowa, the Capitol, and the early workings of state government.
core
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
INTERPRETASI EKOWISATA OLEH PEMANDU WISATA DI KAWASAN PARIWISATA UBUD
Tourism is one sector whose development which very intensively developed by the government. One form of sustainable tourism is ecotourism. Tour guides in ecotourism activities have an important role in connecting tourists with interpreted tourist ...
Ashira Istighfarah +2 more
doaj +1 more source
China Employment Law Update - August 2015 [PDF]
In This Issue: Government Announces Overtime Treatment for Special Holiday in September Significant Amendments Made to Shanghai Collective Contract Regulations MOHRSS Issues Draft Implementation Rules on Employment Contract Law Government Makes ...
Baker & McKenzie
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The impact of behaviors and skills of tour guides in guiding tourist groups. [PDF]
The aim of this study was to reveal the impact of the tour guide's behaviors and skills in guiding tourists groups in an efficient manner. To achieve the aim of the study, a random sample of (117) tour guides were selected and the descriptive approach ...
Dr. Mohammad Shabeb Kassawnh +3 more
doaj
Whale sharks of the western Caribbean: an overview of current research and cnservation efforts and future needs for effective management of the species [PDF]
Whale sharks (Rhincodon typus) are seasonal visitors to four sites in the Western Caribbean, 3 of which are encompassed by the Mesoamerican Barrier Reef.
Graham, Rachel T.
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The dynamic trio: The relationship between passion, perseverance and job satisfaction
This work aims to enhance the understanding of the dynamic relationship between passion, perseverance and job satisfaction among tour guides, recognizing the interconnected nature of these elements and their impact on tourism experience.
Mitja Gorenak +2 more
doaj +1 more source

