Results 81 to 90 of about 191,063 (302)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Sustainable valorization of cultural heritage via tour guides: Turkish case of Ephesus ancient city

open access: yesPASOS Revista de Turismo y Patrimonio Cultural, 2015
The concept of sustainability has become one of the most popular topics of tourism studies. Sustainable tourism emerged as a strong stream of tourism research based on the stance that tourism industry has responsibility for degradation of natural and ...
Mehmet Yavuz CETINKAYA, Zafer OTER
doaj   +1 more source

Development of a Naturalist Course for Manta Tour Guides in Hawaii [PDF]

open access: yes, 2015
The Kona Coast on the island of Hawaii is a world-class destination for those who seek marine wildlife interactions. One activity that sets Kona apart from other worldwide tourist destinations is the opportunity to observe manta rays in the wild.
Laros, Wendy
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Creating (extra)ordinary heritage through film-induced tourism: The case of Dubrovnik and the Game of Thrones [PDF]

open access: yes, 2018
This chapter brings in the perspective on the practices of (re)producing heritage through film imagery in the UNESCO World Heritage Site. More specifically, the chapter discusses the recurrent practices of tour guides in reshaping and recreating the ...
Šegota, Tina
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

The ability to speak English of the local tour guides for promoting tourism at the Aceh Tsunami Museum

open access: yesStudies in English Language and Education, 2018
This research aimed to find out the English language proficiency of the local tour guides at the Aceh Tsunami Museum, Aceh, Indonesia, and the difficulties that they faced in communicating with foreign tourists in English.
Sofyan Abdul Gani, Cut Intan Damayanti
doaj   +1 more source

Gettysburg College & The Battle of Gettysburg: A Civil War Walking Tour

open access: yes, 2013
Originally compiled by John Rudy as a student project in 2007 at Gettysburg College, this new, revised edition of the Civil War Walking Tour booklet guides a visitor on a truly unique campus tour.
Rudy, John M., \u2707
core  

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