Results 101 to 110 of about 941,918 (300)
The molecular basis of chemical toxicity.
Environmental Health Perspectives, 1985 Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biological systems and to assess our ...
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Predicting Chemical Toxicity Effects Based on Chemical-Chemical Interactions
PLoS ONE, 2013 Toxicity is a major contributor to high attrition rates of new chemical entities in drug discoveries. In this study, an order-classifier was built to predict a series of toxic effects based on data concerning chemical-chemical interactions under the assumption that interactive compounds are more likely to share similar toxicity profiles.
Lei Chen +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Toxic Chemicals and Peripheral Neuropathy [PDF]
Proceedings of the Royal Society of Medicine, 1969 +11 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2016 26-27The US Government has proposed a new TSCA (Toxic Substances Control Act) law that proposes to give the US Environmental Protection Agency (EPA) new powers to obtain information on chemicals, and mandates safety tests before they can be ...
Ushadevi, K.S.
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Toxic chemicals produced from atmospheric reactions [PDF]
, 2018 [第31回環境工学連合講演会 = he 31th National Congress for Environmental Studies] 2018/05/22-2018/05/22, 日本学術会議講堂, 主催: 日本学術会議 土木工学・建築学委員会Atmospheric nitrated polycyclic aromatic hydrocarbons (NPAHs) have been shown to have toxic effects.
亀田, 貴之
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Direct and Indirect Cognitive and Psychological Consequences of Workplace Neurotoxic Exposure [PDF]
, 2009 Cognitive assessments were conducted on aircraft crew who reported symptoms following exposure to jet oil engine emissions from BAe-146 aircraft. Results demonstrated impairments on tests of reaction time, processing speed and fine motor skills in most ...
Coxon, Leonie
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