Results 111 to 120 of about 941,918 (300)

Toxic textiles: Potential health risks associated with toxic chemicals in clothing [PDF]

open access: yes
Toxic textiles: Potential health risks associated with toxic chemicals in clothing: Maria A. Muñoz and Pamela J. Lein from the University of California, Davis, focus on the potential health risks associated with toxic chemicals in clothing.
Muñoz, Maria A, Lein, Pamela J
core   +1 more source

Chemical Incidents and Gathering Information of Toxicity

open access: yesChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Miyako, Yamamoto, Kaoru, Morikawa
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Baseline Toxic Mixtures of Non-Toxic Chemicals: “Solubility Addition” Increases Exposure for Solid Hydrophobic Chemicals

open access: yes, 2015
This study addresses the question whether hydrophobic organic chemicals exerting no toxicity at their solubility limit (saturation) can form a toxic mixture.
Martin Holmstrup (761777)   +5 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Evaluation of liposome-water partitioning for predicting bioaccumulation potential of hydrophobic organic chemicals. [PDF]

open access: yes, 2009
Considering the importance of bioaccumulation factors (BAFs) in risk assessment of chemicals and the ethical issues and complexity of the determination of these factors in standard tests with living organisms, there is a need for alternative approaches ...
van der Heijden, S.A.   +3 more
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

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