The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
PROCESSED FOODS – ARE THEY SAFE? [PDF]
Exploratory Animal and Medical Research, 2017 Processed foods contain high calorie food particles at different forms added with different additives. United States Food and Drug Administration (FDA) recommend safe use of different chemicals as food additives in processed foods.
Shibabrata Pattanayak
doaj
Toxic Substances Control Act (TSCA) Implementation: How the Amended Law Has Failed to Protect Vulnerable Populations from Toxic Chemicals in the United States. [PDF]
Environ Sci Technol, 2022 Rayasam SDG +4 more
europepmc +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Identification of newly formed toxic chemicals in E-cigarette aerosols with Orbitrap mass spectrometry and implications on E-cigarette control. [PDF]
Eur J Mass Spectrom (Chichester), 2021 Yan B +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Awareness of toxic chemicals in entertainment and educational materials
Revista Ciencias Biomédicas, 2012 Introduction: security offered by the materials used to manufacture some tools forrecreational activities and/or educational assistance may not have been adequatelycontrolled.
Fontalvo-Rivera Dilia +6 more
doaj
Cases of near misses in chemical laboratories of universities and their countermeasures
Emergency Management Science and TechnologyIn this study, interviews with undergraduate and graduate students about incidents that did not result in an accident but felt dangerous (so-called near miss incidents) that occurred in the chemical laboratory at the university (to which the author ...
Takashiro Akitsu, Daisuke Nakane
doaj +1 more source
Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR's toxicological profile database. [PDF]
Int J Environ Health Res, 2022 Buser MC, Pohl HR, Abadin HG.
europepmc +1 more source