Results 51 to 60 of about 235,288 (260)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Male reproductive health and environmental xenoestrogens [PDF]

, 1996
EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or ...
Christiansen, Pia, Meyts, E. Rajpert-De, B Jégou, Larsen, JC, Skakkebæk, N. E., J Toppari, Jensen, T K, Christiansen, P, O Meyer, McLachlan, J A, Christiansen, Peter, Jensen, TK, Sumpter, J., Leffers, H, R Sharpe, N Keiding, Sumpter, J, Scheike, T., McLachlan, J. A., Meyer, O, Keiding, N., Leffers, H., Guillette, L. J., Giwercman, Alexander, Larsen, John Christian, H Leffers, L J Guillette, T Scheike, Keiding, N, J A McLachlan, Müller, J, Giverman, A., T K Jensen, P Christiansen, Meyer, Otto A., Toppari, J., Rajpert-De Meyts, E, Larsen, J C, Skakkebaek, N E, J Müller, E Rajpert-De Meyts, Grandjean, P, Skakkebæk, NE, Guillette, L J, Jouannet, P, P Grandjean, Meyts, ERD, Guillette, LJJ, N E Skakkebaek, Müller, Jørn, McLachlan, JA, Müller, J., Sharpe, R., Jegou, B., Sharpe, R, Toppari, J, J Sumpter, J C Larsen, P Jouannet, Jensen, T. K., Sumpter, JP, Jouannet, P., A Giwercman, Jégou, B, Grandjean, P., Giwercman, A, Scheike, T   +66 more
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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Toxic exposure in America: estimating fetal and infant health outcomes [PDF]

We examine the effect of toxic exposure on U.S. infant and fetal mortality rates between 1989 and 2002 from toxic pollution released by facilities reporting to the Toxic Release Inventory (TRI).
Linda T.M. Bui, Nikhil Agarwal, Chanont Banternghansa   +2 more
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Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Toxic textiles: Potential health risks associated with toxic chemicals in clothing [PDF]

Toxic textiles: Potential health risks associated with toxic chemicals in clothing: Maria A. Muñoz and Pamela J. Lein from the University of California, Davis, focus on the potential health risks associated with toxic chemicals in clothing.
Muñoz, Maria A, Lein, Pamela J
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Toxic chemicals produced from atmospheric reactions [PDF]

, 2018
[第31回環境工学連合講演会 = he 31th National Congress for Environmental Studies] 2018/05/22-2018/05/22, 日本学術会議講堂, 主催: 日本学術会議 土木工学・建築学委員会Atmospheric nitrated polycyclic aromatic hydrocarbons (NPAHs) have been shown to have toxic effects.
亀田, 貴之
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