Results 91 to 100 of about 1,068 (138)

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6584-6594, August 2026.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas   +11 more
wiley   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

open access: yesEuropean Journal of Dental Education, Volume 30, Issue 3, Page 881-895, August 2026.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer   +4 more
wiley   +1 more source

STEVENS-JOHNSON SYNDROME — TOXIC EPIDERMAL NECTROLYSIS IN CHILDREN. PART I. DETERMINATION, ETIOLOGY, PATHOGENESIS, CLINICAL MANIFESTATIONS, SYSTEMIC TREATMENT

open access: yesПедиатрическая фармакология, 2011
Part I of the literature review provides modern terminology and classification of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which is now considered different ways of treating the single pathological process induced in children ...
V.F. Zhernosek, T.P. Dyubkova
doaj   +2 more sources

Multidisciplinary management of antiepileptic drug-induced toxic epidermal necrolysis in a young woman

open access: yesBiomédica: revista del Instituto Nacional de Salud
Toxic epidermal necrolysis is a rare, life-threatening dermatological emergency characterized by extensive epidermal detachment and mucosal involvement,  associated with high morbidity and mortality.
Salman Khan, Priti Singh, Rana Salieva
doaj   +1 more source

Toxic Epidermal Necrolysis

open access: yesInternational Journal of Clinical Practice, 1967
M J, Samuels, M D, Readett
openaire   +2 more sources

Exploring skin adverse events and mechanisms of apalutamide using data mining algorithms and network pharmacology

open access: yesFrontiers in Pharmacology
BackgroundSkin adverse events of apalutamide pose a major challenge to its clinical use, particularly the severe and difficult to identify toxic epidermal necrolysis.
Yaqing Chen   +4 more
doaj   +1 more source

Intrapartum Toxic Epidermal Necrolysis [PDF]

open access: yesArchives of Disease in Childhood, 1964
W P, SWEETNAM, A J, BARLOW, R G, DENNISS
openaire   +2 more sources

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

open access: yesMedisur
Stevens-Johnson syndrome and toxic epidermal necrolysis are severe mucocutaneous rare diseases with high morbid mortality characterized by generalized epidermal necrosis and skin detachment; They are distinguished from each other due to the extent of ...
Jeanneth Elizabeth Jami Carrera   +3 more
doaj  

Toxic epidermal necrolysis

Journal of Dermatological Treatment, 1998
1coined the term necrolysis to describe four clinical cases characterised pathologically by necrosis of the epidermis, and clinically by widespread epidermolysis—a loosening of the epidermis leading to blister formation, exfoliation, or both. Large sheets of skin had peeled off, leaving a raw, denuded base.
Laurence Le Cleach, J-C Roujeau
exaly   +3 more sources

Toxic Epidermal Necrolysis

International Journal of Dermatology, 1991
Toxic Epidermal Necrolysis (TEN) is an acute, severe, often life-threatening skin reaction, which is characterized by an extensive necrosis and detachment of the epidermis and mucous membranes. It has been observed worldwide and affects people of both sexes and all ages.
T E, Rohrer, A R, Ahmed
  +10 more sources

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