Results 101 to 110 of about 1,068 (138)
Some of the next articles are maybe not open access.
Postgraduate Medicine, 1972
Toxic epidermal necrolysis, although uncommon, warrants the attention of all clinicians because of its serious prognosis. The clinical course of this cutaneous syndrome is similar in children and adults, but some differences do exist. Because diagnostic laboratory tests are not available, the physician must recognize the disorder by its distinctive ...
A J, Ammann, W H, Tooley, R, Hong
+7 more sources
Toxic epidermal necrolysis, although uncommon, warrants the attention of all clinicians because of its serious prognosis. The clinical course of this cutaneous syndrome is similar in children and adults, but some differences do exist. Because diagnostic laboratory tests are not available, the physician must recognize the disorder by its distinctive ...
A J, Ammann, W H, Tooley, R, Hong
+7 more sources
Current Drug Safety, 2012
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Florence, Castelain, Philippe, Humbert
openaire +3 more sources
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Florence, Castelain, Philippe, Humbert
openaire +3 more sources
International Journal of Dermatology, 1996
Abstract Background. Most studies on drug‐induced toxic epidermal necrolysis (TEN) report a high mortality rate. This has been attributed partly to the use of corticosteroids for its treatment. However, we consider corticosteroids to be the sheet anchor for saving the patients having TEN. Materials and Methods.
J S, Pasricha +4 more
openaire +4 more sources
Abstract Background. Most studies on drug‐induced toxic epidermal necrolysis (TEN) report a high mortality rate. This has been attributed partly to the use of corticosteroids for its treatment. However, we consider corticosteroids to be the sheet anchor for saving the patients having TEN. Materials and Methods.
J S, Pasricha +4 more
openaire +4 more sources
Journal of Burn Care & Rehabilitation, 1997
Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
J T, Murphy, G F, Purdue, J L, Hunt
openaire +2 more sources
Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
J T, Murphy, G F, Purdue, J L, Hunt
openaire +2 more sources
Dermatologic Clinics, 2000
Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
openaire +2 more sources
Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
openaire +2 more sources
Medical Clinics of North America, 1975
Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
openaire +2 more sources
Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
openaire +2 more sources
JAMA: The Journal of the American Medical Association, 1965
This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
G, BAILEY, J M, ROSENBAUM, B, ANDERSON
openaire +2 more sources
This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
G, BAILEY, J M, ROSENBAUM, B, ANDERSON
openaire +2 more sources
International Journal of Dermatology, 1992
Toxic epidermal necrolysis is a severe mucocutaneous reaction pattern characterized by fever, systemic toxicity, tenderness, erythema, and widespread exfoliation. Lyell1 of Glasgow, Scotland, and Lang and Walker2 of Cape Town, South Africa, independently described this syndrome in 1956.
openaire +2 more sources
Toxic epidermal necrolysis is a severe mucocutaneous reaction pattern characterized by fever, systemic toxicity, tenderness, erythema, and widespread exfoliation. Lyell1 of Glasgow, Scotland, and Lang and Walker2 of Cape Town, South Africa, independently described this syndrome in 1956.
openaire +2 more sources
Interventions for toxic epidermal necrolysis
Cochrane Database of Systematic Reviews, 2002Toxic epidermal necrolysis is a rare condition where a drug reaction induces skin loss, similar to that seen in extensive burns. It is associated with high morbidity and mortality and there is no clear agreement on effective treatment.To assess the effects of all interventions for the treatment of toxic epidermal necrolysis.We searched the Cochrane ...
S, Majumdar +3 more
openaire +2 more sources
Plastic and Reconstructive Surgery, 1978
We present a case report of a patient with toxic epidermal necrolysis (TEN), associated with therapy with trimethoprin and sulfamethoxazole. Because of the similarity of TEN to an extensive partial-thickness burn, and the favorable response to the treatment used in burns, surgeons who treat burns should be familiar withe disease and take an active role
G, Anhalt, C F, Snelling
openaire +2 more sources
We present a case report of a patient with toxic epidermal necrolysis (TEN), associated with therapy with trimethoprin and sulfamethoxazole. Because of the similarity of TEN to an extensive partial-thickness burn, and the favorable response to the treatment used in burns, surgeons who treat burns should be familiar withe disease and take an active role
G, Anhalt, C F, Snelling
openaire +2 more sources