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Medical Clinics of North America, 1975
Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
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Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
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Dermatologic Clinics, 2000
Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
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Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
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Archives of Dermatology, 1960
A striking dermatologic disease resembling scalding, namely acute pemphigus, has been recently renamed toxic epidermal necrolysis by Lyell,1or epidermolysis necroticans combustiformis by Soltermann.2Already, mention has been made in the literature of a score or more examples under these names, and the disease is apparently not rare.3However, no recent ...
B, POTTER, R, AUERBACH, A L, LORINCZ
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A striking dermatologic disease resembling scalding, namely acute pemphigus, has been recently renamed toxic epidermal necrolysis by Lyell,1or epidermolysis necroticans combustiformis by Soltermann.2Already, mention has been made in the literature of a score or more examples under these names, and the disease is apparently not rare.3However, no recent ...
B, POTTER, R, AUERBACH, A L, LORINCZ
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Plastic and Reconstructive Surgery, 1978
We present a case report of a patient with toxic epidermal necrolysis (TEN), associated with therapy with trimethoprin and sulfamethoxazole. Because of the similarity of TEN to an extensive partial-thickness burn, and the favorable response to the treatment used in burns, surgeons who treat burns should be familiar withe disease and take an active role
G, Anhalt, C F, Snelling
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We present a case report of a patient with toxic epidermal necrolysis (TEN), associated with therapy with trimethoprin and sulfamethoxazole. Because of the similarity of TEN to an extensive partial-thickness burn, and the favorable response to the treatment used in burns, surgeons who treat burns should be familiar withe disease and take an active role
G, Anhalt, C F, Snelling
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International Journal of Dermatology, 1992
Toxic epidermal necrolysis is a severe mucocutaneous reaction pattern characterized by fever, systemic toxicity, tenderness, erythema, and widespread exfoliation. Lyell1 of Glasgow, Scotland, and Lang and Walker2 of Cape Town, South Africa, independently described this syndrome in 1956.
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Toxic epidermal necrolysis is a severe mucocutaneous reaction pattern characterized by fever, systemic toxicity, tenderness, erythema, and widespread exfoliation. Lyell1 of Glasgow, Scotland, and Lang and Walker2 of Cape Town, South Africa, independently described this syndrome in 1956.
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The Lancet, 1998
1coined the term necrolysis to describe four clinical cases characterised pathologically by necrosis of the epidermis, and clinically by widespread epidermolysis—a loosening of the epidermis leading to blister formation, exfoliation, or both. Large sheets of skin had peeled off, leaving a raw, denuded base.
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1coined the term necrolysis to describe four clinical cases characterised pathologically by necrosis of the epidermis, and clinically by widespread epidermolysis—a loosening of the epidermis leading to blister formation, exfoliation, or both. Large sheets of skin had peeled off, leaving a raw, denuded base.
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Archives of Dermatology, 1985
To the Editor.— We read with much interest the report of Westly and Wechsler 1 on granulocytopenia as a prognostic factor in drug-induced toxic epidermal necrolysis. However, the cause of the granulocytopenia remained obscure. The authors speculated that hypersensitivity immunologic reactions might cause the drug-induced toxic epidermal necrolysis as ...
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To the Editor.— We read with much interest the report of Westly and Wechsler 1 on granulocytopenia as a prognostic factor in drug-induced toxic epidermal necrolysis. However, the cause of the granulocytopenia remained obscure. The authors speculated that hypersensitivity immunologic reactions might cause the drug-induced toxic epidermal necrolysis as ...
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Cutis, 1980
Toxic epidermal necrolysis (TEN) is a disorder characterized by the sudden onset of widespread erythema and tenderness of the skin with rapid progression to desquamation of sheets of epidermis, resembling scalding. Although the clinical picture is similar in many instances, toxic epidermal necrolysis is subdivided into two main clinicopathologic types,
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Toxic epidermal necrolysis (TEN) is a disorder characterized by the sudden onset of widespread erythema and tenderness of the skin with rapid progression to desquamation of sheets of epidermis, resembling scalding. Although the clinical picture is similar in many instances, toxic epidermal necrolysis is subdivided into two main clinicopathologic types,
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