Results 171 to 180 of about 17,217 (221)
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International Journal of Dermatology, 1991
Toxic Epidermal Necrolysis (TEN) is an acute, severe, often life-threatening skin reaction, which is characterized by an extensive necrosis and detachment of the epidermis and mucous membranes. It has been observed worldwide and affects people of both sexes and all ages.
T E, Rohrer, A R, Ahmed
+10 more sources
Toxic Epidermal Necrolysis (TEN) is an acute, severe, often life-threatening skin reaction, which is characterized by an extensive necrosis and detachment of the epidermis and mucous membranes. It has been observed worldwide and affects people of both sexes and all ages.
T E, Rohrer, A R, Ahmed
+10 more sources
Australasian Journal of Dermatology, 1996
SUMMARYToxic epidermal necrolysis (TEN) is a rare, drug‐induced, life‐threatening syndrome with widespread epidermal loss and mucosal erosions. The classification, pathophysiology, clinical features and treatment are discussed in this review. Prognosis has improved as admission to a burns unit and early treatment of infection has become standard ...
J S, Pasricha +4 more
+6 more sources
SUMMARYToxic epidermal necrolysis (TEN) is a rare, drug‐induced, life‐threatening syndrome with widespread epidermal loss and mucosal erosions. The classification, pathophysiology, clinical features and treatment are discussed in this review. Prognosis has improved as admission to a burns unit and early treatment of infection has become standard ...
J S, Pasricha +4 more
+6 more sources
Current Drug Safety, 2012
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Florence, Castelain, Philippe, Humbert
openaire +3 more sources
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Florence, Castelain, Philippe, Humbert
openaire +3 more sources
Postgraduate Medicine, 1972
Toxic epidermal necrolysis, although uncommon, warrants the attention of all clinicians because of its serious prognosis. The clinical course of this cutaneous syndrome is similar in children and adults, but some differences do exist. Because diagnostic laboratory tests are not available, the physician must recognize the disorder by its distinctive ...
A J, Ammann, W H, Tooley, R, Hong
+7 more sources
Toxic epidermal necrolysis, although uncommon, warrants the attention of all clinicians because of its serious prognosis. The clinical course of this cutaneous syndrome is similar in children and adults, but some differences do exist. Because diagnostic laboratory tests are not available, the physician must recognize the disorder by its distinctive ...
A J, Ammann, W H, Tooley, R, Hong
+7 more sources
Journal of Burn Care & Rehabilitation, 1997
Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
J T, Murphy, G F, Purdue, J L, Hunt
openaire +2 more sources
Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
J T, Murphy, G F, Purdue, J L, Hunt
openaire +2 more sources
Dermatologic Clinics, 2000
Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
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Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2 ...
P, Wolkenstein, J, Revuz
openaire +2 more sources
Lancet, The, 1998
1coined the term necrolysis to describe four clinical cases characterised pathologically by necrosis of the epidermis, and clinically by widespread epidermolysis—a loosening of the epidermis leading to blister formation, exfoliation, or both. Large sheets of skin had peeled off, leaving a raw, denuded base.
exaly +3 more sources
1coined the term necrolysis to describe four clinical cases characterised pathologically by necrosis of the epidermis, and clinically by widespread epidermolysis—a loosening of the epidermis leading to blister formation, exfoliation, or both. Large sheets of skin had peeled off, leaving a raw, denuded base.
exaly +3 more sources
Medical Clinics of North America, 1975
Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
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Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
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JAMA: The Journal of the American Medical Association, 1965
This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
G, BAILEY, J M, ROSENBAUM, B, ANDERSON
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This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
G, BAILEY, J M, ROSENBAUM, B, ANDERSON
openaire +2 more sources