Results 201 to 210 of about 29,800 (242)
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Medical Clinics of North America, 1975
Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
Michael Jarratt, Andrew H. Rudolph
openaire +7 more sources
Toxic epidermal necrolysis is one of the rarest events -- a dermatologic emergency. The clinical presentation is characteristic -- disseminate erythema and widespread bullous necrosis of the epidermis and mucous membranes. Toxicity is universal and mortality is substantial even with prompt and intensive therapy. Drugs are the most commonly incriminated
Michael Jarratt, Andrew H. Rudolph
openaire +7 more sources
International Journal of Dermatology, 2020
The use of checkpoint inhibitors for treatment of advanced malignancies is increasing. Rashes, pruritus, and more rarely, reactions resembling Stevens‐Johnsons syndrome (SJS) or toxic epidermal necrolysis (TEN) may occur secondary to checkpoint ...
N. Maloney +4 more
semanticscholar +1 more source
The use of checkpoint inhibitors for treatment of advanced malignancies is increasing. Rashes, pruritus, and more rarely, reactions resembling Stevens‐Johnsons syndrome (SJS) or toxic epidermal necrolysis (TEN) may occur secondary to checkpoint ...
N. Maloney +4 more
semanticscholar +1 more source
Current Drug Safety, 2012
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Philippe Humbert, Florence Castelain
openaire +4 more sources
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous drug-induced syndrome that causes massive keratinocyte apoptosis and therefore hydro-electrolytic disorders and systemic infection. TEN approximately affects one to two cases per million per year. Mortality rate may reach thirty percent of cases. Thus, TEN constitute a therapeutic emergency at
Philippe Humbert, Florence Castelain
openaire +4 more sources
JAMA: The Journal of the American Medical Association, 1965
This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
George Bailey +2 more
+9 more sources
This syndrome, resembling scalding of the skin, is presented, with a review of the literature and description of a fatal case. The disease consists of a prodrome of malaise, lethargy, and fever, followed by erythema and massive bullae formation. Pathologically, there is epidermal necrosis and vesication at the dermal-epidermal junction, but the dermis ...
George Bailey +2 more
+9 more sources
Archives of Dermatology, 1985
To the Editor.— We read with much interest the report of Westly and Wechsler 1 on granulocytopenia as a prognostic factor in drug-induced toxic epidermal necrolysis. However, the cause of the granulocytopenia remained obscure. The authors speculated that hypersensitivity immunologic reactions might cause the drug-induced toxic epidermal necrolysis as ...
B. J. Vermeer, F. J. H. Claas
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To the Editor.— We read with much interest the report of Westly and Wechsler 1 on granulocytopenia as a prognostic factor in drug-induced toxic epidermal necrolysis. However, the cause of the granulocytopenia remained obscure. The authors speculated that hypersensitivity immunologic reactions might cause the drug-induced toxic epidermal necrolysis as ...
B. J. Vermeer, F. J. H. Claas
openaire +3 more sources
Australasian Journal of Dermatology, 1996
SUMMARYToxic epidermal necrolysis (TEN) is a rare, drug‐induced, life‐threatening syndrome with widespread epidermal loss and mucosal erosions. The classification, pathophysiology, clinical features and treatment are discussed in this review. Prognosis has improved as admission to a burns unit and early treatment of infection has become standard ...
Dimond Rl, Hoss Dm, Feder Hm
openaire +5 more sources
SUMMARYToxic epidermal necrolysis (TEN) is a rare, drug‐induced, life‐threatening syndrome with widespread epidermal loss and mucosal erosions. The classification, pathophysiology, clinical features and treatment are discussed in this review. Prognosis has improved as admission to a burns unit and early treatment of infection has become standard ...
Dimond Rl, Hoss Dm, Feder Hm
openaire +5 more sources
Journal of Burn Care & Rehabilitation, 1997
Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
Gary F. Purdue +2 more
openaire +3 more sources
Toxic epidermal necrolysis (TEN) is a poorly understood and devastating condition. It is usually diagnosed in a primary care setting. Treatment of severe cases by burn care personnel is usually by referral. In this review, we report excessive mortality rates associated with prolonged use of systemic steroid therapy and delayed referral (more than 1 ...
Gary F. Purdue +2 more
openaire +3 more sources
Erythema multiforme, Stevens‐Johnson syndrome/toxic epidermal necrolysis – diagnosis and treatment
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2020Prior to the first international consensus classification published in 1993, the clinical distinction between erythema multiforme (EM), Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had been subject to uncertainty and controversy ...
P. Grünwald +3 more
semanticscholar +1 more source
Journal of dermatological treatment (Print), 2020
Background: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) is one of severe cutaneous adverse reactions with low morbidity but high mortality.
Shan Zhang +4 more
semanticscholar +1 more source
Background: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) is one of severe cutaneous adverse reactions with low morbidity but high mortality.
Shan Zhang +4 more
semanticscholar +1 more source
Journal of the European Academy of Dermatology and Venereology, 2020
The SCORTEN score is a specific predictor of mortality for patients with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). There is little evidence in support of the common immunomodulating therapies for SJS/TEN.
I. Torres-Navarro +3 more
semanticscholar +1 more source
The SCORTEN score is a specific predictor of mortality for patients with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). There is little evidence in support of the common immunomodulating therapies for SJS/TEN.
I. Torres-Navarro +3 more
semanticscholar +1 more source