Results 11 to 20 of about 9,182 (184)

Toxic epidermal necrolysis following a furosemide injection: a case report [PDF]

Journal of Medical Case Reports
Background Toxic epidermal necrolysis is a life threatening adverse cutaneous reaction mostly following drug administration. It is characterized by extensive detachment of skin and mucous membranes with a more than 30% total body surface area involvement.
Clare Nakubulwa, Deogratius Galagala, Ivan Gidudu   +2 more
doaj   +2 more sources

Review of Toxic Epidermal Necrolysis [PDF]

International Journal of Molecular Sciences, 2016
Toxic epidermal necrolysis (TEN) is a rare but life threatening mucocutaneous reaction to drugs or their metabolites. It is characterised by widespread keratinocyte apoptosis and sloughing of the skin, erosions of the mucous membranes, painful blistering, and severe systemic disturbance.
Victoria Harris, Christopher Jackson, Alan Cooper   +2 more
openaire   +4 more sources

Multidisciplinary Treatment in Toxic Epidermal Necrolysis

International Journal of Environmental Research and Public Health, 2023
Toxic epidermal necrolysis, Leyll’s syndrome (TEN), is a rare mucocutaneous blistering disease burdened with high mortality rates. The diagnosis of TEN is based on clinical symptoms and histopathological findings. In approximately 90% of cases, it is a severe adverse reaction to drugs.
Agnieszka Surowiecka, Wioletta Barańska-Rybak, Jerzy Strużyna   +2 more
openaire   +5 more sources

Toxic epidermal necrolysis [PDF]

Journal of the American Academy of Dermatology, 2007
Toxic epidermal necrolysis (TEN) is an unpredictable, life-threatening drug reaction associated with a 30% mortality. Massive keratinocyte apoptosis is the hallmark of TEN. Cytotoxic T lymphocytes appear to be the main effector cells and there is experimental evidence for involvement of both the Fas-Fas ligand and perforin/granzyme pathways.
Frederick A, Pereira, Adarsh Vijay, Mudgil, David M, Rosmarin   +2 more
  +7 more sources

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Medisur
Stevens-Johnson syndrome and toxic epidermal necrolysis are severe mucocutaneous rare diseases with high morbid mortality characterized by generalized epidermal necrosis and skin detachment; They are distinguished from each other due to the extent of ...
Jeanneth Elizabeth Jami Carrera, John Sebastián Carvajal Gavilanes, Karen Gabriela Sulca Espín, Dennis Alexander Montenegro Montenegro   +3 more
doaj   +1 more source

Terbinafine-induced Toxic Epidermal Necrolysis in Pregnancy: A Case Report

Journal of Nepal Medical Association, 2023
Toxic epidermal necrolysis in pregnancy is a rare disease that can have an adverse effect on Toxic epidermal necrolysis in pregnancy is a rare disease that can have an adverse effect on pregnancy outcomes.
Ramesh Lamichhane, Mahendra Raj Pandey, Ayushma Dhungana, Anjana Lamsal   +3 more
doaj   +1 more source

Bronchiolitis obliterans associated with toxic epidermal necrolysis induced by infection: A case report and literature review

Frontiers in Pediatrics, 2023
BackgroundStevens-Johnson syndrome/toxic epidermal necrolysis has a severe impact on patients' eyes, genital mucosa, and many other organs. Bronchiolitis obliterans is a rare complication of Stevens-Johnson syndrome/toxic epidermal necrolysis.Data ...
Jingwei Liu, Haibo Yan, Chunfeng Yang, Yumei Li   +3 more
doaj   +1 more source

Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome

Dermatology Reports, 2023
The treatment of epidermal necrolysis in pediatric patients remains a major challenge. Cyclosporine A has emerged as a promising therapy for epidermal necrolysis in adults; however, its efficacy in children is unclear.
Shinta Trilaksmi Dewi, Laily Noor Qomariah, Widya Khairunisa Sarkowi, Monika Puspitasari, Miya Khalidah, Marcella Anggatama, Dwinanda Almira Rizkiani, Kristiana Etnawati, Sri Awalia Febriana   +8 more
doaj   +1 more source

Toxic epidermal necrolysis [PDF]

F1000Research, 2016
Toxic epidermal necrolysis (TEN) is a rare, life-threatening drug-induced skin disease with a mortality rate of approximately 30%. The clinical hallmark of TEN is a marked skin detachment caused by extensive keratinocyte cell death associated with mucosal involvement. The exact pathogenic mechanism of TEN is still uncertain.
Hoetzenecker, Wolfram, Mehra, Tarun, Saulite, Ieva, Glatz, Martin, Schmid-Grendelmeier, Peter, Guenova, Emmanuella, Cozzio, Antonio, French, Lars E   +7 more
openaire   +4 more sources

Pembrolizumab-Induced Toxic Epidermal Necrolysis

Case Reports in Oncology, 2022
Immunotherapy has nowadays become part of the mainstay of treatment for several cancers. In this report, we present a case of toxic epidermal necrolysis (TEN) occurring as a relatively rare complication of pembrolizumab, which is a humanized monoclonal ...
Luca Borg, Malcolm Buhagiar, Elisa La Ferla, David Pisani, Janabel Said, Michael J. Boffa   +5 more
doaj   +1 more source